2011 Fiscal Year Final Research Report
Functional analysis of dockkopf 3 in liver development and regeneration
| Project/Area Number |
21590414
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KANO Junko 筑波大学, 医学医療系, 講師 (60334059)
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Masayuki 筑波大学, 医学医療系, 教授 (00198582)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肝臓 / 細胞 / がん関連遺伝子 / 発生 / 分化 |
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| Research Abstract |
To elucidate the function of Dickkopf 3 (Dkk3), a possible regulator in liver development and regeneration, we have investigated the molecular mechanism of anti-apoptotic function in Dkk3-overexpressing cells, the receptor of Dkk3, and the contribution to liver regeneration in Dkk3-knockout mice. In result, it was revealed that the suppression of reactive oxygen species was involved in the anti-apoptotic function, and possible candidates for the receptors were found. On the other hand, no significant contribution was shown in the analysis using Dkk3-knockout mouse model.
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