Observation of in vivo dynamics of macrophage subsets based on expression of lectin molecule

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590417
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kyoto University
• Principal Investigator: TAKAHARA Kazuhiko 京都大学, 生命科学研究科, 講師 (90301233)
• Co-Investigator(Kenkyū-buntansha): INABA Kayo 京都大学, 生命科学研究科, 教授 (00115792)
• Project Period (FY): 2009 – 2011
• Keywords: 細胞

Research Abstract

Dendritic cells/macrophages play important roles in immune system. A part of these cells is derived from monocytes in blood cells generated by bone marrow. However, dynamics of monocytes isn' t fully clear, because of lack of appropriate markers. We found that SIGNR3, a lectin, is a new and useful marker for identification of monocytes. Using a new antibody to SIGNR3, we studied behavior of monocytes in steady and inflammatory states.

Research Products

• [Journal Article] Efficient capture of Calbicans and zymosan by SIGNR1 facilitates TLR2-dependent TNF-αproduction by macrophages (2012)
  • Author(s): Takahara, K., Tokieda, S., Nagaoka, K. and Inaba, K
  • Journal Title: Int. Immunol Volume: 24 Pages: 89-96
• [Journal Article] Difference in fine specificity to polysaccharides of C. albicans mannoprotein between mouse SIGNR1 and human. DC-SIGN. (2012)
  • Author(s): Takahara, K., Tokieda, S., Nagaoka, K., Takeda, T., Kimura, Y. and Inaba, K
  • Journal Title: Infect. Immun Volume: 41 Pages: 1435-44
• [Journal Article] GM-CSF-independent CD1a expression in epidermal Langerhans cells : evidence from human CD1A genome-transgenic mice. (2011)
  • Author(s): Kobayashi, C., Shiina, T., Tokioka, A., Hattori, Y., Komori, T., Kobayashi-Miura, M., Takizawa, T., Takahara, K., Inaba, K., Inoko, H., Takeya, M., Dranoff, G. and Sugita, M.
  • Journal Title: J. Invest. Dermatol. Volume: 132 Pages: 241-244
• [Journal Article] C-type lectin SIGNR1 enhances cellular oxidative burst response against C. albicans in cooperation with Dectin-1. (2011)
  • Author(s): Takahara, K., Tokieda, S., Nagaoka, K., Takeda, T., Kimura, Y. and Inaba, K
  • Journal Title: Eur. J. Immunol Volume: 88 Pages: 913-924
• [Journal Article] Expression of C-type lectin, SIGNR3, on subsets of dendritic cells, macrophages and monocytes (2010)
  • Author(s): Nagaoka, K., Takahara, K., Minamino, K., Takeda, T., Yoshida, Y. and Inaba, K
  • Journal Title: J. Leukoc. Biol Volume: 88 Pages: 913-924
• [Presentation] C型レクチンSIGNR1はDectin-1と共同して細胞のoxidative burstを促進する (2011)
  • Author(s): 高原和彦
  • Organizer: 日本免疫学会
  • Place of Presentation: 幕張
  • Year and Date: 2011-11-28
• [Presentation] Recognition of Calbicans by SIGNR1 and subsequent responses in vivo (2010)
  • Author(s): Kazuhiko Takahara
  • Organizer: 10th Awaji International Forum for Infection and Immunity
  • Place of Presentation: 淡路
  • Year and Date: 2010-09-09
• [Presentation] Ly6Chigh SIGNR3-monocytes can differentiate to CD11b+ dendritic cells in subcutaneous lymph nodes under steady-state condition. (2010)
  • Author(s): Koji Nagaoka
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-25
• [Presentation] Binding properties of SIGNR1 against surface mannoprotein of Candida albicans. (2010)
  • Author(s): Sumika Tokieda
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-25
• [Remarks]
  • URL: http://zoo.zool.kyoto-u.ac.jp/imm/