2011 Fiscal Year Final Research Report
Analysis of diabetes mellitus in mutant cryptochrome1 transgenic mice
| Project/Area Number |
21590429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAYASAKA Kiyoshi 山形大学, 医学部, 教授 (20142961)
NAKAJIMA Osamu 山形大学, 医学部, 教授 (80312841)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 糖尿病 / インスリン分泌不全 / 膵ベータ細胞 / MODY(若年発症成人型糖尿病) / 概日リズム / 生物時計 |
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| Research Abstract |
We previously showed that transgenic mice ubiquitously expressing mouse cryptochrome1 (CRY1) with a mutation in cysteine414 display not only anomalous circadian behavior but also symptoms of diabetes mellitus.
In order to clarify yet uncovered pathogenesis of the diabetes, in this study we examined age-dependent characteristics of the disorder of the transgenic mice, and found that the symptom resemble human MODY (maturity onset diabetes mellitus of the young). We showed that the mice showed from young age reduced expression of insulin gene along with several genes whose expression is involved in the function of ss-cells, which can cause early-onset diabetes similar to human MODY.
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Research Products
(18 results)
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[Remarks] 岡野聡,中島修:"変異型CRY1過剰発現マウスが示す明暗条件下での給餌性概日リズムの異常"第19回山形分子生物学セミナー.(20111116).山形大学医学部(山形県)
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[Remarks] 岡野聡,早坂清,中島修:"変異型CRY1過剰発現マウスの給餌性概日リズム"第10回山形ニューロサイエンス研究会.(20090613).山形大学医学部(山形県)
