2011 Fiscal Year Final Research Report
The gene expression profiling of lesional skin mast cells collected by laser capture microdissection
| Project/Area Number |
21590431
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kinki University |
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Principal Investigator |
ITO Akihiko 近畿大学, 医学部, 教授 (80273647)
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| Project Period (FY) |
2009 – 2011
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| Keywords | アトピー性皮膚炎 / 接着分子 / 炎症 / mRNA / CADM1 |
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| Research Abstract |
Atopic dermatitis(AD)-like lesional and non-lesional mast cells were separately collected by laser capture microdissection. Increased expression of CADM1 in lesional mast cells appeared to be a cause of enhanced sensory nerve-mast cell interaction in AD.
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[Journal Article] Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking2011
Author(s)
Fukui R, Saitoh S, Kanno A, Onji M, Shibata T, Ito A, Onji M, Matsumoto M, Akira S, Yoshida N, and Miyake K
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Journal Title
Immunity
Volume: 35
Pages: 69-81
Peer Reviewed
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[Journal Article] Aberrant expression of tumor suppressors CADM1 and 4.1B, in invasive lesions of primary breast cancer2011
Author(s)
Takahashi Y, Iwai M, Kawai T, Arakawa A, Ito T, Sakurai-Yageta M, Ito A, Goto A, Saito M, Kasumi F, and Murakami Y
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Journal Title
Breast Cancer
Volume: (in press)
Peer Reviewed
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[Journal Article] CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I(HTLV-I) transformed cells and adult T-cell leukemia(ATL) cells : possible involvement of CADM1 in pathogenesis of ATL2010
Author(s)
Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, Stanbridge EJ, and Murakami Y
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Journal Title
J Biol Chem
Volume: 285
Pages: 15511-15522
Peer Reviewed
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[Journal Article] Epigenetic silencing of a proapoptotic cell adhesion molecule, the immunoglobulin superfamily member IGSF4, by promoter CpG methylation protects Hodgkin lymphoma cells from apoptosis2010
Author(s)
Murray PG, Fan Y, Davies G, Ying J, Geng H, Ng KM, Li H, Gao Z, Wei W, Bose S, Anderton J, Kapatai G, Reynolds G, Ito A, Marafioti T, Woodman CB, Ambinder R, and Tao Q
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Journal Title
Am J Pathol
Volume: 177
Pages: 1480-1490
Peer Reviewed
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