2011 Fiscal Year Final Research Report
Analysis of the mechanisms for the promoting effect of diabetes mellitus on carcinogenesis : An experimental study using insulin-deficient mice
| Project/Area Number |
21590439
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kochi University |
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Principal Investigator |
GANG-HONG Lee 高知大学, 教育研究部・医療学系, 教授 (10261405)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肝がん / 肺がん / 糖尿病 / インスリン / 化学発がん |
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| Research Abstract |
Diabetes mellitus(DM) is an epidemiological risk factor for human carcinogenesis. In order to clarify the relationship between insulin, the key hormone relevant to DM, and carcinogenesis, we analyzed chemically induced liver and lung carcinogenesis in genetically insulin-deficient, diabetic mice. Relative to euinsulinemia, the insulin deficiency promoted liver tumor development, albeit decreasing lung tumors. Thus, the effects of insulin deficiency were found tissue-specific. The mechanisms of promotion by DM of carcinogenesis should be more complex than generally assumed
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[Journal Article] Review of renal carcinoma associated with Xp11. 2 translocations/ TFE3 gene fusions with focus on pathobiological aspect2012
Author(s)
Kuroda N, Mikami S, Pan CC, Cohen RJ, Hes O, Michal M, Nagashima Y, Tanaka Y, Inoue K, Shuin T, Lee G-H
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Journal Title
Histol Histopathol
Volume: 27
Pages: 133-140
Peer Reviewed
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