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2011 Fiscal Year Final Research Report

Elucidation of mechanisms underlying production of myeloid derived suppressor cells and possible involvement of interleukin-17 in the process.

Research Project

  • PDF
Project/Area Number 21590443
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

INABA Tohru  京都府立医科大学, 医学研究科, 講師 (60203204)

Co-Investigator(Kenkyū-buntansha) KITA Masakazu  京都府立医科大学, 医学研究科, 準教授 (60153087)
HIRAI Hirai  京都大学, 医学研究科, 助教 (50315933)
Project Period (FY) 2009 – 2011
Keywords骨髄球系抑制細胞 / インターロイキン17 / 造血 / 腫瘍 / 免疫
Research Abstract

The developmental process of Myeloid derived suppressor cells(MDSCs) remains unknown. In IL-17A or IL-17F knockout mice, MDSCs were induced at similar frequency as wild type mice. Taking into account the previous report showing that IL-17 receptor signaling is necessary for MDSCs induction, these results suggest that IL-17A and IL-17F are functionally redundant in MDSCs induction.

  • Research Products

    (7 results)

All 2011 2010 Other

All Journal Article (3 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Galection-9 ameliorates acute Graft-versus-host disease through the induction of T-cell apoptosis2011

    • Author(s)
      Sakai K, Kawata E, Ashihara E, Nakagawa Y, Yamauchi A, Yao Y, Nagao R, Tanaka R, Yokota A, Takeuchi T, Hirai H, Kimura S, Hirashima M, Yoshimura N, Maekawa T
    • Journal Title

      Eur J Immunol

      Volume: 41 Pages: 67-75

  • [Journal Article] Growth inhibition of imatinib-resistant CML cells with the T315I mutation and hypoxia-adaptation by AV65-a novel Wnt/β-catenin signaling inhibitor2011

    • Author(s)
      Nagao R, Ashihara E, Kimura S, Strovel JW, Yao H, Takeuchi M, Tanaka R, Hayashi Y, Hirai H, Padia J, Strand K, Maekawa T
    • Journal Title

      Cancer Lett

      Volume: 312(1) Pages: 91-100

  • [Journal Article] Use of bicistronic vectors in combination with flow cytometry to screen for effective small interfering RNA target sequences2010

    • Author(s)
      Kamio N, Hirai H, Ashihara E, Tenen DG, Maekawa T, Imanishi J
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 393 Pages: 498-503

  • [Presentation] BCR/ABL-Mediated Myeloid Expansion Is Promoted by C/EBPβ, a Regulator of Emergency Granulopoiesis2011

    • Author(s)
      Hayashi Y, Hirai H, Yao H, Yoshioka S, Satake S, Kamio N, Miura Y, Ashihara E, Fujiyama Y, Tenen DG, Maekawa T
    • Organizer
      53rd ASH Annual Meeting and Exposition
    • Place of Presentation
      San Diego, US
    • Year and Date
      20111211-13
  • [Presentation] The developmental process of myeloid-derived suppressor cells in the bone marrow of tumor-bearing mice2010

    • Author(s)
      Nagao R, Hirai H, Satake S, Yao H, Tanaka R, Hayashi Y, Ashihara E, Maekawa T
    • Organizer
      Kyoto University Global COE "Center for Frontier Medicine" International Symposium/Retreat 2010
    • Place of Presentation
      Hyogo, Japan
    • Year and Date
      2010-11-05
  • [Presentation] A flow cytometry-based method for screening of effective small interfering RNA target sequences2010

    • Author(s)
      Kamio N, Hirai H, Satake S, Tanaka R, Nagao R, Yao H, Hayashi Y, Takeuchi M, Ashihara E, Maekawa T
    • Organizer
      第16回日本遺伝子治療学会年次学術集会
    • Place of Presentation
      栃木
    • Year and Date
      2010-07-02
  • [Remarks] 京都大学医学部附属病院輸血細胞治療部

    • URL

      http://dtm.kuhp.kyoto-u.ac.jp/

URL: 

Published: 2013-07-31  

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