2011 Fiscal Year Final Research Report
Elucidation of mechanisms underlying production of myeloid derived suppressor cells and possible involvement of interleukin-17 in the process.
Project/Area Number |
21590443
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
INABA Tohru 京都府立医科大学, 医学研究科, 講師 (60203204)
|
Co-Investigator(Kenkyū-buntansha) |
KITA Masakazu 京都府立医科大学, 医学研究科, 準教授 (60153087)
HIRAI Hirai 京都大学, 医学研究科, 助教 (50315933)
|
Project Period (FY) |
2009 – 2011
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Keywords | 骨髄球系抑制細胞 / インターロイキン17 / 造血 / 腫瘍 / 免疫 |
Research Abstract |
The developmental process of Myeloid derived suppressor cells(MDSCs) remains unknown. In IL-17A or IL-17F knockout mice, MDSCs were induced at similar frequency as wild type mice. Taking into account the previous report showing that IL-17 receptor signaling is necessary for MDSCs induction, these results suggest that IL-17A and IL-17F are functionally redundant in MDSCs induction.
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[Journal Article] Galection-9 ameliorates acute Graft-versus-host disease through the induction of T-cell apoptosis2011
Author(s)
Sakai K, Kawata E, Ashihara E, Nakagawa Y, Yamauchi A, Yao Y, Nagao R, Tanaka R, Yokota A, Takeuchi T, Hirai H, Kimura S, Hirashima M, Yoshimura N, Maekawa T
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Journal Title
Eur J Immunol
Volume: 41
Pages: 67-75
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[Journal Article] Growth inhibition of imatinib-resistant CML cells with the T315I mutation and hypoxia-adaptation by AV65-a novel Wnt/β-catenin signaling inhibitor2011
Author(s)
Nagao R, Ashihara E, Kimura S, Strovel JW, Yao H, Takeuchi M, Tanaka R, Hayashi Y, Hirai H, Padia J, Strand K, Maekawa T
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Journal Title
Cancer Lett
Volume: 312(1)
Pages: 91-100
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[Presentation] BCR/ABL-Mediated Myeloid Expansion Is Promoted by C/EBPβ, a Regulator of Emergency Granulopoiesis2011
Author(s)
Hayashi Y, Hirai H, Yao H, Yoshioka S, Satake S, Kamio N, Miura Y, Ashihara E, Fujiyama Y, Tenen DG, Maekawa T
Organizer
53rd ASH Annual Meeting and Exposition
Place of Presentation
San Diego, US
Year and Date
20111211-13
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