2011 Fiscal Year Final Research Report

Molecular mechanism of hormone therapy resistance in cancers

Research Project

Project/Area Number	21590450
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Experimental pathology
Research Institution	National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
Principal Investigator	KUWATA Takeshi 独立行政法人国立がん研究センター, 臨床開発センター, 医長 (00327321)
Co-Investigator(Kenkyū-buntansha)	OCHIAI Atsushi 独立行政法人国立がん研究センター, 臨床開発センター, 部長 (60183034)
Project Period (FY)	2009 – 2011
Keywords	腫瘍
Research Abstract	Molecular mechanism of hormone therapy resistance, especially in prostate cancer, was investigated. Interleukin(IL)-1beta showed tumor inhibitory effect in several prostate cancer cell lines including LNCap, while a previous report suggested possible involvement of IL-1beta in the resistance. Constitutive expression of these enzymes support tumor cell growth in castrated nude mice. Thus we concluded that these results suggested expression of androgenic enzymes may be involved in acquired resistant against hormone therapy in cancer.

(4 results)