2011 Fiscal Year Final Research Report
Analysis of immunosuppression mechanism by sialic acids on cancer cells, and a feasible study to control immune reaction using sialylated carbohydrates.
| Project/Area Number |
21590454
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
IKEHARA Yuzuri 独立行政法人産業技術総合研究所, 糖鎖医工学研究センター, 研究チーム長 (10311440)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 炎症 / 糖鎖 / がん / 免疫制御 |
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| Research Abstract |
This study was conducted to increase knowledge about immune evasion by cancer cells, focusing on appearing sialic acids(Sialyl Tn antigen) with development and progression of cancer. Using xenotransplantation and syngenic transplantation animal models, and sialic acid coated liposome, we demonstrated that sialic acids had regulatory function to suppress tumor immunity. Additionally, we established methods to generate a series of immortalized cells that are available to investigate further mechanism of immune evasion.
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Research Products
(22 results)
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[Journal Article] PCR Detection of Babesia ovata from Cattle Reared in Japan and Clinical Significance of Co-Infection with Theileria orientalis2012
Author(s)
Sivakumar T, Tagawa M, Yoshinari T, Ybanez AP, Igarashi I, Ikehara Y, Hata H, Kondo S, Matsumoto K, Inokuma H, Yokoyama N
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Journal Title
Peer Reviewed
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[Journal Article] Strategy for Glycoproteomics : Identification of Glyco-Alteration Using Multiple Glycan Profiling Tool2009
Author(s)
Ito H, Kuno A, Sawaki H, Sogabe M, Ozaki H, Tanaka Y, Mizokami M, Shoda JI, Angata T, Sato T, Hirabayashi J, Ikehara Y, Narimatsu H
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Journal Title
J Proteome Res
Volume: 8(3)
Pages: 1358-67
Peer Reviewed
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