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2011 Fiscal Year Final Research Report

Analysis of immunosuppression mechanism by sialic acids on cancer cells, and a feasible study to control immune reaction using sialylated carbohydrates.

Research Project

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Project/Area Number 21590454
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

IKEHARA Yuzuri  独立行政法人産業技術総合研究所, 糖鎖医工学研究センター, 研究チーム長 (10311440)

Project Period (FY) 2009 – 2011
Keywords炎症 / 糖鎖 / がん / 免疫制御
Research Abstract

This study was conducted to increase knowledge about immune evasion by cancer cells, focusing on appearing sialic acids(Sialyl Tn antigen) with development and progression of cancer. Using xenotransplantation and syngenic transplantation animal models, and sialic acid coated liposome, we demonstrated that sialic acids had regulatory function to suppress tumor immunity. Additionally, we established methods to generate a series of immortalized cells that are available to investigate further mechanism of immune evasion.

  • Research Products

    (22 results)

All 2012 2011 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (7 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Establishment and characterization of novel gastric signet-ring cell and non signet-ring cell poorly differentiated adenocarcinoma cell lines with low and high malignant potential2012

    • Author(s)
      Murakami H, Nakanishi H, Tanaka H, Ito S, Misawa K, Ito Y, Ikehara Y, Kondo E, Kodera Y
    • Journal Title

      Gastric Cancer

    • Peer Reviewed
  • [Journal Article] PCR Detection of Babesia ovata from Cattle Reared in Japan and Clinical Significance of Co-Infection with Theileria orientalis2012

    • Author(s)
      Sivakumar T, Tagawa M, Yoshinari T, Ybanez AP, Igarashi I, Ikehara Y, Hata H, Kondo S, Matsumoto K, Inokuma H, Yokoyama N
    • Journal Title

      J Clin Microbiol

    • Peer Reviewed
  • [Journal Article] Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model2012

    • Author(s)
      Ozaki H, Matsuzaki H, Ando H, Kaji H, Nakanishi H, Ikehara Y, Narimatsu H
    • Journal Title

      Clin Exp Metastasis

      Volume: 29(3) Pages: 229-238

    • Peer Reviewed
  • [Journal Article] Different levels of Sialyl-Tn Antigen expressed on MUC16 in Endometriosis and Ovarian Cancer Patients2012

    • Author(s)
      Akita K, Yoshida S, Ikehara Y, Shirakawa S, Toda M, Inoue M, Kitawaki J, Nakanishi H, Narimatsu H, Nakada H
    • Journal Title

      Int J Gynecol Cancer

    • Peer Reviewed
  • [Journal Article] Characterization of Splenic Cells during the Early Phase of Infection with Neuropathogenic Mouse Hepatitis Virus2011

    • Author(s)
      Kashiwazaki H, Taguchi F, Ikehara Y, Watanabe R
    • Journal Title

      Jpn J Infect Dis

      Volume: 64(3) Pages: 256-259

    • Peer Reviewed
  • [Journal Article] Single-walled carbon nanohorns as drug carriers : adsorption of prednisolone and anti-inflammatory effects on arthritis2011

    • Author(s)
      Nakamura M, Tahara Y, Ikehara Y, Murakami T, Tsuchida K, Iijima S, Waga I, Yudasaka M.
    • Journal Title

      Nanotechnology

      Volume: 22(46) Pages: 465102

    • DOI

      DOI:10.1088/0957-4484/22/46/465102

    • Peer Reviewed
  • [Journal Article] Irradiation experiments on a mouse using a mild-plasma generator for medical applications2010

    • Author(s)
      SAKAKITA H. and IKEHARA Y
    • Journal Title

      Plasma and Fusion Research

      Volume: S2117 Pages: 1-4

    • Peer Reviewed
  • [Journal Article] Targeted delivery of oligomannose-coated liposome to the omental micrometastasis by peritoneal macrophages from patients with gastric cancer2010

    • Author(s)
      Matsui M., Shimizu Y., Kodera Y., Kondo, K. Ikehara Y., and Nakanishi H
    • Journal Title

      Cancer Sci

      Volume: 101(7) Pages: 1670-7

    • Peer Reviewed
  • [Journal Article] Recent advancements in cytotoxic T lymphocyte generation methods using carbohydrate coated liposomes2010

    • Author(s)
      Ikehara Y., Yamaguchi T., Yamanaka M.
    • Journal Title

      J. Biomedicine and Biotechnology

      Volume: 242539 Pages: 1-8

    • DOI

      doi:10.1155/2010/242539

    • Peer Reviewed
  • [Journal Article] Immunization of oligomannose-coated liposome-entrapped NcGRA7 protects dams and offspring from Neospora caninum infection in mice2009

    • Author(s)
      Nishikawa Y, Zhang H, Ikehara Y, Kojima N, Xuan X, Yokoyama N
    • Journal Title

      Clin Vaccine Immunol

      Volume: 16(6) Pages: 792-729

    • Peer Reviewed
  • [Journal Article] Effect of oligomannose-coated liposome-based vaccine on rodent babesiosis2009

    • Author(s)
      Ishigame T., Takabatake N., Iseki H., Ota N., Koyama A., Igarashi I., Nishikawa Y., Ikehara Y., Kojima N., Yokoyama N
    • Journal Title

      J. Protozoology Research

      Volume: 19(1) Pages: 10-23

    • Peer Reviewed
  • [Journal Article] Strategy for Glycoproteomics : Identification of Glyco-Alteration Using Multiple Glycan Profiling Tool2009

    • Author(s)
      Ito H, Kuno A, Sawaki H, Sogabe M, Ozaki H, Tanaka Y, Mizokami M, Shoda JI, Angata T, Sato T, Hirabayashi J, Ikehara Y, Narimatsu H
    • Journal Title

      J Proteome Res

      Volume: 8(3) Pages: 1358-67

    • Peer Reviewed
  • [Presentation] グライコプロテオミクス研究に必要な実験手技2011

    • Author(s)
      池原譲
    • Organizer
      第8回日本病理学会カンファレンス
    • Place of Presentation
      ホテルブエナビスタ(長野県)
    • Year and Date
      2011-08-05
  • [Presentation] 糖鎖分析技術を取り入れた組織細胞化学研究2011

    • Author(s)
      池原譲
    • Organizer
      組織細胞化学会講習会
    • Place of Presentation
      三鷹市公会堂(東京都)
    • Year and Date
      2011-08-04
  • [Presentation] グライコプロテオミクスによる肝細胞がんに対する新規糖鎖マーカーの探索2011

    • Author(s)
      池原譲
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-04-30
  • [Presentation] 糖鎖研究の進展に基づく癌の検出と治療戦略2010

    • Author(s)
      池原譲
    • Organizer
      日本組織細胞化学会
    • Place of Presentation
      秋葉原コンベショナルセンター(東京)
    • Year and Date
      2010-09-06
  • [Presentation] Cancer vaccine delivery system using oligomannose coated liposomes2010

    • Author(s)
      Ikehara Y.
    • Organizer
      World Congress of Vaccine-2010
    • Place of Presentation
      北京国際会議場(Beijin)
    • Year and Date
      2010-03-25
  • [Presentation] 肝線維化の進展を測定できる新しい糖鎖バイオマーカーの開発とその有用性について2009

    • Author(s)
      池原譲、成松久
    • Organizer
      日本分子腫瘍マーカー学
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-09-30
  • [Presentation] A novel drug delivery system. Carbohydrate recognition-based and controlled release system using intra-peritoneal macrophages as a cellular vehicle2009

    • Author(s)
      Ikehara Y., Niwa T., Ikehara S., Biao L., Ohashi N., Kobayashi T., Shimizu Y., Kojima N., Nakanishi H.
    • Organizer
      AACR 100th Annual Meeting
    • Place of Presentation
      Denver, CO(USA)
    • Year and Date
      2009-04-20
  • [Book] 組織細胞化学2011、糖鎖分析技術を取り入れた組織細胞化学研究2011

    • Author(s)
      池原譲
    • Total Pages
      155-166
    • Publisher
      日本組織細胞化学会出版
  • [Book] 組織細胞化学2010、糖鎖・糖タンパク質の生物機能解明と医療応用2011

    • Author(s)
      池原譲
    • Total Pages
      197-207
    • Publisher
      日本組織細胞化学会出版
  • [Remarks]

    • URL

      http://unit.aist.go.jp/rcmg/rcmg-ga/ci/index.html

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Published: 2013-07-31  

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