2011 Fiscal Year Final Research Report
Coagulation factor VII producing tumors and their release of microparticles with coagulation initiating capacity
| Project/Area Number |
21590455
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | 地方独立行政法人神奈川県立病院機構 (2011)
Kanagawa Cancer Center Research Institute (2009-2010) |
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Principal Investigator |
MIYAGI Yohei 地方独立行政法人神奈川県立病院機構, 臨床研究所, 総括部長 (00254194)
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| Co-Investigator(Kenkyū-buntansha) |
KOIZUME Shiro 神奈川県立がんセンター臨床研究所, 主任研究員 (60416063)
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| Project Period (FY) |
2009 – 2011
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| Keywords | TF / 組織因子 / factor VII / 血液凝固第VII因子 / 低酸素 / 低血清 / 遺伝子発現 |
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| Research Abstract |
Physiological expression of blood coagulation factor VII(fVII) is generally restricted to hepatocytes. In the present study, we found that breast cancer tumor cells produce fVII ectopically, and release fVII containing microparticles(MPs) with a high coagulation initiating capacity into the microenvironment, especially under hypoxic condition. In addition, we partly clarified a novel regulatory mechanism of gene expression under hypoxia combined with depleted nutrients, which could be a target for new cancer therapies.
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Research Products
(10 results)
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[Journal Article] HNF-4 independent synthesis of coagulation factor VII in breast cancer cells and its inhibition by targeting selective histone acetyltransferases2009
Author(s)
Koizume S, Yokota N, Miyagi E, Hirahara F, Nakamura Y, Sakuma Y, Yoshida A, Kameda Y, Tsuchiya E, Ruf W, Miyagi Y.
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Journal Title
Mol Cancer Res
Volume: 7(12)
Pages: 1928-1936
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[Presentation]2011
Author(s)
Shiro Koizume, Etsuko Miyagi, Fumiki Hirahara, Yoshiyasu Nakamura, Eiju Tsuchiya, Wolfram Ruf, and Yohei Miyagi
Organizer
The 102nd AACR Annual Meeting 2011
Place of Presentation
Orlando, FL
Year and Date
2011-10-03
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