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2011 Fiscal Year Final Research Report

Induction of neuroprotective microenvironment and intervention of neurodegenerative condition by the intra-bone marrow bone-marrow transplantation

Research Project

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Project/Area Number 21590458
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionInstitute for Developmental Research, Aichi Human Service Center

Principal Investigator

SHIMADA Atsuyoshi  愛知県心身障害者コロニー発達障害研究所, 病理学部, 室長 (50311444)

Project Period (FY) 2009 – 2011
Keywords骨髄移植 / 老化 / 神経変性
Research Abstract

We hypothesized that brain aging might be caused by a loss of neuroprotective function from brain immune cells. Mice with accelerated brain aging lacked the neuroprotective responses exerted by neuron-glia interaction after being challenged with brain tissue injury. When these diseased mice received bone marrow transplantation from normal mouse donors, donor-derived marrow cells entered the recipients' brains and differentiated into brain immune cells. These results indicate the possibility of preventing brain aging by bone marrow transplantation.

  • Research Products

    (39 results)

All 2012 2011 2010 2009 Other

All Journal Article (13 results) (of which Peer Reviewed: 12 results) Presentation (23 results) Book (3 results)

  • [Journal Article] 脳と免疫系の相互作用という観点から老化促進モデルマウスをとらえる2012

    • Author(s)
      島田厚良、石井さなえ
    • Journal Title

      基礎老化研究

      Volume: 36(1) Pages: 13-20

    • Peer Reviewed
  • [Journal Article] Senescence-accelerated mice(SAMs) as a model for brain aging and immunosenescence2011

    • Author(s)
      Shimada, A. and Hasegawa-Ishii, S
    • Journal Title

      Aging Dis

      Volume: 2 Pages: 414-436

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed?term=Senescence-accelerated%20mice%20(SAMs)%20as%20a%20model%20for%20brain%20aging%20and%20immunosenescence

    • Peer Reviewed
  • [Journal Article] 免疫系と神経系の接点から老化促進モデルマウスをとらえる2011

    • Author(s)
      島田厚良、石井さなえ
    • Journal Title

      日本老年医学会雑

      Volume: 48(5) Pages: 439-446

  • [Journal Article] Amelioration of 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells2011

    • Author(s)
      Hoshino, S., Kurishima, A., Inaba, M., Ando, Y., Fukui, T., Uchida, K., Nishio, A., Iwai, H., Yokoi, T. Ito, T., Hasegawa-Ishii, S., Shimada, A., Li, M., Okazaki, K., and Ikehara, S
    • Journal Title

      J. Gastroenterol

      Volume: 46 Pages: 1368-1381

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed?term=Amelioration%20of%202%2C4%2C6-trinitrobenzene%20sulfonic%20acid-induced%20colitis%20in%20mice%20by%20immunoregulatory%20dendritic%20cells

    • Peer Reviewed
  • [Journal Article] Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury2011

    • Author(s)
      Furukawa, A., Kawamoto, Chiba, Y., Takei, S., Hasegawa-Ishii, S., Kawamura, N., Yoshikawa, K., Hosokawa, M., Oikawa, S., Kato, M., and Shimada, A.
    • Journal Title

      Neurobiol. Dis

      Volume: 43 Pages: 706-714

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed?term=Proteomic%20identification%20of%20hippocampal%20proteins%20vulnerable%20to%20oxidative%20stress%20in%20excitotoxin-induced%20acute%20neuronal%20injury.%20

    • Peer Reviewed
  • [Journal Article] Morphological impairments in microglia precede age-related neuronal degeneration in senescence-accelerated mice2011

    • Author(s)
      Hasegawa-Ishii, S., Takei, S., Chiba, Y., Furukawa, A., Umegaki, H., Iguchi, A., Kawamura, N., Yoshikawa, K., Hosokawa, M., and Shimada, A.
    • Journal Title

      Neuropathology

      Volume: 31 Pages: 20-8

    • DOI

      doi:10.1111/j.1440-1789.2010.01126.x

    • Peer Reviewed
  • [Journal Article] Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system2011

    • Author(s)
      Yoshikawa, K., Takei, S., Hasegawa-Ishii, S., Chiba, Y., Furukawa, A., Kawamura, N., Hosokawa, M., Woodward, D. F., Watanabe, K., and Shimada, A.
    • Journal Title

      Brain Res

      Volume: 1367 Pages: 22-32

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed?term=Preferential%20localization%20of%20prostamide%2Fprostaglandin%20F%20synthase%20in%20myelin%20sheaths%20of%20the%20central%20nervous%20system

    • Peer Reviewed
  • [Journal Article] Defects in cytokine-mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence-accelerated mouse2011

    • Author(s)
      Hasegawa-Ishii, S., Takei, S., Inaba, M., Umegaki, H., Chiba, Y., Furukawa, A., Kawamura, N., Hosokawa, M., and Shimada, A.
    • Journal Title

      Brain Behav. Immun

      Volume: 25 Pages: 83-100

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed?term=Defects%20in%20cytokine-mediated%20neuroprotective%20glial%20responses%20to%20excitotoxic%20hippocampal%20injury%20in%20senescence-accelerated%20mouse

    • Peer Reviewed
  • [Journal Article] The eosin-shadow method : a selective enhancement of light microscopic visualization of pancreatic zymogen granules on hematoxylin-eosin sections2010

    • Author(s)
      Takei, S., Tokuhira, Y., Shimada, A., Hosokawa, M., and Fukuoka, S
    • Journal Title

      Anat. Sci. Int

      Volume: 85 Pages: 245-250

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed?term=The%20eosin-shadow%20method%3A%20a%20selective%20enhancement%20of%20light%20microscopic%20visualization%20of%20pancreatic%20zymogen%20granules%20on%20hematoxylin-eosin%20sections

    • Peer Reviewed
  • [Journal Article] Oxidatively generated DNA damage induced by 3-amino-5-mercapto-1, 2, 4-triazole, a metabolite of carcinogenic amitrole2010

    • Author(s)
      Furukawa, A., Oikawa, S., Harada, K., Sugiyama, H., Hiraku, Y., Murata, M., Shimada, A., and Kawanishi, S
    • Journal Title

      Mut. Res. Fund. Mol. Mech. Mutag

      Volume: 694 Pages: 7-12

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/?term=Oxidatively%20generated%20DNA%20damage%20induced%20by%203-amino-5-mercapto-1%2C2%2C4-triazole%2C%20a%20metabolite%20of%20carcinogenic%20amitrole

    • Peer Reviewed
  • [Journal Article] Proteomic analysis of aging brain in SAMP10 mouse : a model of age-related cerebral degeneration2010

    • Author(s)
      Furukawa, A., Oikawa, S., Hasegawa-Ishii, S., Chiba, Y., Kawamura, N., Takei, S., Yoshikawa, K., Hosokawa, M., Kawanishi, S., and Shimada, A.
    • Journal Title

      Mech. Ageing Dev

      Volume: 131 Pages: 379-388

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed?term=Proteomic%20analysis%20of%20aging%20brain%20in%20SAMP10%20mouse%3A%20a%20model%20of%20age-related%20cerebral%20degeneration

    • Peer Reviewed
  • [Journal Article] c-Ret-mediated hearing loss in mice with Hirschsprung disease2010

    • Author(s)
      Ohgami, N., Ida-Eto, M., Shimotake, T., Sakashita, N., Sone, M., Nakashima, T., Tabuchi, K., Hoshino, T., Shimada, A., Tsuzuki, T., Yamamoto, M., Sobue, G., Jijiwa, M., Asai, N., Hara, A., Takahashi, M., Kato, M
    • Journal Title

      Proc. Natl. Acad. Sci. U. S. A.

      Volume: 107 Pages: 13051-13056

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/20616061

    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of aggresomal proteins in glial cytoplasmic inclusions in multiple system atrophy

    • Author(s)
      Chiba, Y., Takei, S., Kawamura, N., Kawaguchi, Y., Sasaki, K., Hasegawa-Ishii, S., Furukawa, A., Hosokawa, M., and Shimada, A.
    • Journal Title

      Neuropathol. Appl. Neurobiol

      Volume: (in press)

    • DOI

      doi:10.1111/j.1365-2990.2011.01229.x

    • Peer Reviewed
  • [Presentation] 免疫系と神経系の接点から老化促進モデルマウスをとらえる2011

    • Author(s)
      島田厚良
    • Organizer
      日本基礎老化学会シンポジウム"日本の基礎老化研究の現状と展望"-日本基礎老化学会
    • Place of Presentation
      野田市
    • Year and Date
      2011-10-08
  • [Presentation] Immunohistochemical demonstration of enhanced prostaglandin F_<2α> production following kainic acid-induced seizures in rat hippocampus2011

    • Author(s)
      Takei S, Hasegawa-Ishii S, Uekawa A, Furukawa A, Chiba Y, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A
    • Organizer
      Bio Active Lipid Meeting
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2011-09-19
  • [Presentation] SAMP10に見られるサイトカインを介した神経保護的グリア応答の低下2011

    • Author(s)
      石井さなえ、稲葉宗夫、武井史郎、河村則子、千葉陽一、細川昌則、島田厚良
    • Organizer
      SAM研究協議会
    • Place of Presentation
      岐阜市
    • Year and Date
      2011-07-08
  • [Presentation] Defects in cytokine-mediated neuroprotective glial responses to excitotoxic hippocampal injury in senescence-accelerated mouse2011

    • Author(s)
      Hasegawa-Ishii S, Takei S, Shimada A
    • Organizer
      18^<th> Annual Meeting of The PsychoNeuroImmunology Research Society
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-06-09
  • [Presentation] カイニン酸誘導てんかん発作に伴う海馬プロスタグランジンF2α産生亢進の免疫組織学的解析2011

    • Author(s)
      武井史郎、石井さなえ、上川篤志、千葉陽一、河村則子、Woodward DF、渡部紀久子、島田厚良
    • Organizer
      日本神経病理学会
    • Place of Presentation
      京都市
    • Year and Date
      2011-06-04
  • [Presentation] 老化促進モデルマウスに見られるサイトカインを介した神経保護的グリア応答機能の低下2011

    • Author(s)
      石井さなえ、武井史郎、稲葉宗夫、千葉陽一、古川絢子、河村則子、細川昌則、島田厚良
    • Organizer
      日本神経病理学会
    • Place of Presentation
      京都市
    • Year and Date
      2011-06-04
  • [Presentation] The distribution of prostamide/prostaglandin F synthase in the developing and adult mouse central nervous system2010

    • Author(s)
      Shimada, A., Yoshikawa, K., Takei, S., Hasegawa-Ishii, S., Chiba, Y., Furukawa, A., Kawamura, N., Woodward, D. F., Watanabe, K
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-10
  • [Presentation] Prostamide/prostaglandin F synthaseのマウス中枢神経系および培養オリゴデンドロサイトにおける分布2010

    • Author(s)
      千葉陽一、島田厚良、吉川圭介、武井史郎、石井さなえ、古川絢子、河村則子、David F Woodward、渡部紀久子
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-09-03
  • [Presentation] 脳組織防御機構の破綻と加齢性神経変性2010

    • Author(s)
      島田厚良
    • Organizer
      日本基礎老化学会第33回大会,シンポジウム:老化と疾患
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-06-18
  • [Presentation] 加齢性神経変性におけるミクログリアの関与と骨髄内骨髄移植による実験的治療2010

    • Author(s)
      石井さなえ、稲葉宗夫、武井史郎、古川絢子、河村則子、千葉陽一、細川昌則、池原進、島田厚良
    • Organizer
      日本基礎老化学会第33回大会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-06-17
  • [Presentation] A novel type of PGF synthase belonging to the thioredoxin-like superfamily2010

    • Author(s)
      Watanabe, K. and Shimada, A
    • Organizer
      Keystone Symposium "Bioactive Lipids : Biochemistry and Diseases"
    • Place of Presentation
      京都市
    • Year and Date
      2010-06-07
  • [Presentation] 興奮毒性による海馬損傷における酸化損傷タンパク質の生成2010

    • Author(s)
      古川絢子、島田厚良、河村則子、武井史郎、千葉陽一、石井さなえ、細川昌則
    • Organizer
      日本神経病理学会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-23
  • [Presentation] Glial cytoplasmic inclusionはaggresomeとしての性格を有する2009

    • Author(s)
      千葉陽一、島田厚良、武井史郎、河村則子、石井さなえ、古川絢子、佐々木健介、岩城徹、細川昌則
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-09-18
  • [Presentation] 興奮毒性による海馬損傷における酸化損傷タンパク質の生成2009

    • Author(s)
      古川絢子、島田厚良、河村則子、武井史郎、千葉陽一、石井さなえ、細川昌則
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-09-18
  • [Presentation] 促進モデルマウスにみられるミクログリアの異常と神経変性2009

    • Author(s)
      島田厚良、石井さなえ、武井史郎、河村則子、古川絢子、千葉陽一、細川昌則
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋市
    • Year and Date
      2009-09-16
  • [Presentation] SAMP10への骨髄内骨髄移植によるミクログリア再生を介した神経変性の制御2009

    • Author(s)
      島田厚良、石井さなえ、稲葉宗夫、河村則子、武井史郎、古川絢子、千葉陽一、細川昌則、池原進
    • Organizer
      第24回老化促進モデルマウス研究協議会
    • Place of Presentation
      松本市
    • Year and Date
      2009-07-09
  • [Presentation] SAMP10にみられるミクログリアの形態異常と興奮毒性に対する応答異常2009

    • Author(s)
      石井さなえ、島田厚良、千葉陽一、古川絢子、河村則子、武井史郎、細川昌則
    • Organizer
      第24回老化促進モデルマウス研究協議会
    • Place of Presentation
      松本市
    • Year and Date
      2009-07-09
  • [Presentation] 加齢性神経変性疾患における封入体形成へのaggresomeの関与2009

    • Author(s)
      千葉陽一、島田厚良、武井史郎、河村則子、石井さなえ、古川絢子、細川昌則
    • Organizer
      日本基礎老化学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-06-20
  • [Presentation] プロスタグランジン抑制による興奮毒性誘発神経細胞死の制御2009

    • Author(s)
      島田厚良、吉川圭介、北芳博、清水孝雄、石井さなえ、古川絢子、河村則子、千葉陽一
    • Organizer
      第50回日本神経病理学会総会
    • Place of Presentation
      高松市
    • Year and Date
      2009-06-06
  • [Presentation] Glial cytoplasmic inclusionsはaggresomeとしての側面を有する2009

    • Author(s)
      千葉陽一、島田厚良、武井史郎、河村則子、石井さなえ、古川絢子、佐々木健介、岩城徹、細川昌則
    • Organizer
      第50回日本神経病理学会総会
    • Place of Presentation
      高松市
    • Year and Date
      2009-06-05
  • [Presentation] 老化促進モデルマウスにみられるミクログリアの形態異常と興奮毒性に対する応答異常2009

    • Author(s)
      石井さなえ、島田厚良、千葉陽一、古川絢子、河村則子、武井史郎、細川昌則
    • Organizer
      第50回日本神経病理学会総会
    • Place of Presentation
      高松市
    • Year and Date
      2009-06-05
  • [Presentation] SAMP10の加齢性神経変性に伴うタンパク質発現変化に関するプロテオミクス解析2009

    • Author(s)
      古川絢子、島田厚良、及川伸二、千葉陽一、石井さなえ、河村則子、武井史郎、細川昌則
    • Organizer
      第50回日本神経病理学会総会
    • Place of Presentation
      高松市
    • Year and Date
      2009-06-05
  • [Presentation] The distribution of prostamide/prostaglandin F synthase in mouse brain : Developmental changes and localization to the myelin sheath2009

    • Author(s)
      Shimada, A
    • Organizer
      4th International Conference on Phospholipase A_2 and Lipid Mediators Poster Workshop I
    • Place of Presentation
      東京
    • Year and Date
      2009-05-26
  • [Book] Clinical Pathological Conference(C. P. C.)学業の遅れと歩行の異常で発症し、多彩な神経症状が進行した男子症例.「小児神経学の進歩-第39集」(日本小児神経学会教育委員会編)2010

    • Author(s)
      林雅晴、小森拓、島田厚良
    • Total Pages
      129-144
    • Publisher
      診断と治療社
  • [Book] The SAM strain of mice, a higher oxidative stress, age-dependent degenerative disease, and senescence acceleration model. In : Aging and Age-related Disorders, Oxidative Stress in Applied Basic Research and Clinical Practice 3(Bondy, S. C. and Maiese, K. eds.)2010

    • Author(s)
      Chiba, Y., Shimada, A., and Hosokawa, M
    • Total Pages
      359-380
    • Publisher
      Humana Press, New York
  • [Book] SAMP10 strain as a model for the study of brain aging, in T. Takeda, ed. The senescence-accelerated mouse(SAM): Achievements and Future Directions

    • Author(s)
      A. Shimada, A., Hasegawa-Ishii, S., and Furukawa, A
    • Publisher
      Elsevier, Amsterdam(in press)

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Published: 2013-07-31  

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