2011 Fiscal Year Final Research Report
Mechanism of inducing invasive phenotype after VEGF inhibition
| Project/Area Number |
21590459
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses |
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Principal Investigator |
INOUE Masahiro 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 研究所, 総括研究員 (10342990)
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Hiroko 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 研究所, 研究員 (20359300)
OKUYAMA Hiroaki 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 研究所, 総括研究員 (50432373)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 血管新生 / 浸潤 / VEGF / HIF |
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| Research Abstract |
Invasive phenotype was induced by inhibition of VEGF signaling. Hypoxia inducible factor(HIF) is a transcription factor, which regulate hypoxic response. We generated double KO mice of HIF-1αand VEGF in islet cell tumor model mice. Invasive phenotype was remarkably reduced in DKO mice. Levels of E-cadherin expression was reduced in VEGF KO tumors but recovered in DKO mice. Thus, HIF is important for invasive phenotype after angiogenesis inhibition, and decreased E-cadherin levels might be a downstream mechanism.
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[Journal Article] Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner2011
Author(s)
Xie L, Duncan MB, Pahler J, Sugimoto H, Martino M, Lively J, Mundel T, Soubasakos M, Rubin K, Takeda T, Inoue M, Lawler J, Hynes RO, Hanahan D, Kalluri R.
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Journal Title
Proc Natl Acad Sci USA
Volume: 108(24)
Pages: 9939-44
Peer Reviewed
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