2011 Fiscal Year Final Research Report
Immune regulation and protection by mast cells and basophils in parasite infection
| Project/Area Number |
21590470
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIWATA Kenji 東京慈恵会医科大学, 医学部, 准教授 (00241307)
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| Co-Investigator(Renkei-kenkyūsha) |
KARASUYAMA Hajime 東京医科歯科大学, 医歯学総合研究科, 教授 (60195013)
FURUTA Takahisa 東京大学, 医科学研究所, 助教 (30143514)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 寄生虫 / マスト細胞 / 好塩基球 / 感染防御 / マラリア / ダニ / デングウイルス / VEGF / IgE |
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| Research Abstract |
This study demonstrates that mast cells and basophils play major roles in protection and pathogenesis of parasite infections in humans and mice. Mast cells participate in the protection to Plasmodium through TNF and VEGF, and are pathogenic factor in severe Dengue virus infection. Basophils are essential for IgE mediated-acquired immunity to ticks.
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