2011 Fiscal Year Final Research Report
Malarial parasite molecules essential for development from sporoziote to merozoite in the liver stage.
| Project/Area Number |
21590472
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
CHINZEI Yasuo 鈴鹿医療科学大学, 医用工学部, 教授 (60024709)
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| Co-Investigator(Kenkyū-buntansha) |
YUDA Masao (90293779)
IWANAGA Shiro (20314510)
OOTSUKI Makoto (60367878)
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| Project Period (FY) |
2009 – 2011
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| Keywords | マラリア / スポロゾイト / 肝内型原虫 / 遺伝子発現 / ワクチン |
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| Research Abstract |
We established the procedures for isolation of exoerithrocytic form parasites from the infected liver preparations by the cell sorter. We also established the expressed sequence tags database of the exoerythrocytic form parasites in the liver stage from sporozoites to merozotes. We analyzed a parasite molecule which functions to regulate the expression of the genes for development t omerozoites in the liver. Wa found this molecule is a transcription factor. We also showed the possibility of this molecule to be a candidate for development of EEF vaccine.
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