2011 Fiscal Year Final Research Report
Regulatory mechanism of the generation of immune response to Mycobacterium tuberculosis infection
Project/Area Number |
21590479
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Bacteriology (including Mycology)
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Research Institution | Kyoto University |
Principal Investigator |
KAWAMURA Ikuo 京都大学, 医学研究科, 准教授 (20214695)
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Research Collaborator |
SITAR Dewamitta 京都大学, 医学研究科, 大学院生
EDUARDO Hernandez-cuellar 京都大学, 医学研究科, 大学院生
KURENUMA Takeshi 京都大学, 医学研究科, 大学院生
YAMAMOTO Takeshi 京都大学, 医学研究科, 大学院生
FANG Rendong 京都大学, 医学研究科, 大学院生
SYLVIA Daim 京都大学, 医学研究科, 研究生
SHEN Yena 京都大学, 医学研究科, 研究生
QU Huixin 京都大学, 医学研究科, 研究生
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Project Period (FY) |
2009 – 2011
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Keywords | 結核菌 / PD-1 / PPE37 / マクロファージ / T細胞 / IL-1α / IFN-γ |
Research Abstract |
This study was carried out to find out the molecular mechanism as to how Mycobacterium tuberculosis and M. bovis BCG regulate the immune response in infected host. The research revealed that the RD1 locus in the M. tuberculosis genome, which is highly implicated in bacterial virulence, is involved in the production of IL-1α, IL-1βand IL-18 by promoting the activation of calpain and caspase-1, respectively. In addition, it is probable that mycobacterial PPE37 protein contributes to the inhibition of IL-6 and TNF-αproduction from infected macrophages. Moreover, it has been shown that the PD-1 signal pathway is required for the suppression of hyper-immune response to M. tuberculosis infection. On the other hand, it is certain that the efficacy of BCG vaccination is enhanced by the impediment of signal pathway.
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Research Products
(51 results)
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[Journal Article] Critical roles of ASC in flammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection.2011
Author(s)
R. Fang, K. Tsuchiya, I. Kawamura, Y. Shen, H. Hara, S. Sakai, T. Yamamoto, T. Fernandes-Alnemri, R. Yang, E. Hernandez-Cuellar, S. R. Dewamitta, Y. Xu, H. Qu, E. S. Alnemri, and M. Mitsuyama
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Journal Title
J. Immunol
Volume: 187
Pages: 4890-4899
DOI
Peer Reviewed
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[Journal Article] Expression of the Mycobacterium tuberculosis PPE37 protein in Mycobacterium smegmatis induces lowtumour necrosis factor alpha and interleukin 6 production in murine macrophages.2011
Author(s)
S. Daim, T. Nomura, I. Kawamura, H. Hara, K. Tsuchiya, T. Kurenuma, Y. Shen, T. Yamamoto, H. Qu, S. Sakai, Y. Xu, and M. Mitsuyama.
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Journal Title
J. Med. Microbiol
Volume: 60
Pages: 582-591
DOI
Peer Reviewed
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[Journal Article] Toll-like receptor 2-andMyD88-dependent phosphatidylinositol3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by urine macrophages.2010
Author(s)
Y. Xhen, I. Kawamura, T. Nomura, K. Tsuchiya, H. Hara, S. R. Dewamitta, S. Sakai, H. Qu, S. Daim, T. Yamamoto, and M. Mitsuyama
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Journal Title
Infect. Immun
Volume: 78
Pages: 2857-2867
DOI
Peer Reviewed
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[Journal Article] Listeriolyz in O-dependent bacterial entry into the cytoplasm is required for calpain activation and interleukin-1 alpha secretion in macrophages infected with Listeria monocytogenes2010
Author(s)
S. R. Dewamitta T. Nomura, I. Kawamura, H. Hara, K. Tsuchiya, T. Kurenuma, Y. Shen, S. Daim, T. Yamamoto, H. Qu, S. Sakai, Y. Xu, and M. Mitsuyama
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Journal Title
Infect. Immun
Volume: 78
Pages: 1884-1894
DOI
Peer Reviewed
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[Presentation] TLR2-dependent signalis involved in the efficient phagocytosis of Listeria monocytogenes by macrophages2009
Author(s)
S. Yanna, T. Nomura, K. Tsuchiya, H. Hara, S. Sakai, H. Qu, S. Daim, S. R. Dewamitta, T. Yamamoto, I. Kawamura, and M. Mitsuyama.
Organizer
第39回日本免疫学会総会
Place of Presentation
大阪
Year and Date
2009-12-04
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[Presentation] LLO-dependent entry of Listeria monocytogenes into cytoplasm is essential for calcium dependent calpainactivation and IL-1αsecretion in infected macrophages2009
Author(s)
S. R. Dewamitta, 野村卓正, 原英樹, 土屋晃介, 暮沼武士, 申艶那, S. Daim, 酒井俊祐, 屈慧新, 山本武司, 河村伊久雄, 光山正雄
Organizer
第20回日本生体防御学会学術総会
Place of Presentation
東京
Year and Date
2009-07-25
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