2011 Fiscal Year Final Research Report
Analysis of the factors which regulate the expression of carbohydrate transporters and their relevance to virulence of Streptococcus pyogenes
| Project/Area Number |
21590485
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Nagoya City University |
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Principal Investigator |
HASEGAWA Tadao 名古屋市立大学, 大学院・医学研究科, 教授 (10314014)
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| Co-Investigator(Kenkyū-buntansha) |
MINAMI Masaaki 名古屋市立大学, 大学院・医学研究科, 講師 (70418739)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 病原性 |
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| Research Abstract |
Virulent proteins play important roles in the pathogenesis of Streptococcus pyogenes that causes streptococcal toxic shock syndrome. Nutritious conditions, especially carbohydrates are considered to be related with the productions of virulent proteins. For utilizing carbohydrates, bacteria need to take through transporters located in the membrane. In this project, we have studied the roles of transcriptional terminators and two-component regulatory proteins which may regulate the production of transporters. We have showed these regulatory factors were involved for specific carbohydrate utilizations and toxic protein productions.
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Research Products
(15 results)
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[Journal Article] Detection of invasive protein profile of Streptococcus pyogenes M1 isolates from pharyngitis patients2010
Author(s)
Hasegawa T, Okamoto A, Kamimura T, Tatsuno I, Hashikawa S, Yabutani M, Matsumoto M, Yamada K, Isaka M, Minami M, Ohta M
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Journal Title
APMIS
Volume: 118
Pages: 167-78
DOI
Peer Reviewed
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