• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

A quantitative analysis of bacterial flora in the small intestine

Research Project

  • PDF
Project/Area Number 21590488
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionJichi Medical University

Principal Investigator

HIRAI Yoshikazu  自治医科大学, 医学部, 教授 (00127581)

Co-Investigator(Kenkyū-buntansha) SHIMOMURA Hirofumi  自治医科大学, 医学部, 講師 (80348002)
YANO Tomonori  自治医科大学, 医学部, 助教 (30438634)
HAYASHI Shunji  自治医科大学, 医学部, 准教授 (40260765)
Research Collaborator HAYASHI Yoshikazu  自治医科大学, 附属病院, 病院助教
TAKEZAWA Takahito  自治医科大学, 附属病院, 臨床助教(レジデント)
HOSODA Kouich  自治医科大学, 医学部・大学院, 博士
Project Period (FY) 2009 – 2011
Keywords構造 / 生理
Research Abstract

The state of bacterial flora in the small intestine is unclear because of the difficulty for taking samples. We investigated bacteria quantitatively by cultures from small intestinal juices which were taken with a double-balloon endoscopeas a new technique. A few of bacteria were found in the stomach and duodenum, while we detected many bacteria on and after the lower jejunum. In the lower jejunum, anaerobic condition is established. Clostridium difficile was detected from approximately 60% of healthy adults. A half of isolated strains had enterotoxin genes(toxA and toxB). This bacterium was isolated on and after the ileum. In adults infected with Helicobacter pylori, the bacterium was culturable with juices from the stomach to the jejunum.

  • Research Products

    (15 results)

All 2012 2011 2010 2009 Other

All Journal Article (11 results) (of which Peer Reviewed: 7 results) Presentation (2 results) Book (2 results)

  • [Journal Article] Human intestinal spirochetosis in an immunocompromised host : Evaluation of eradication therapy by endoscopy, histopathology and bacteriology2012

    • Author(s)
      Takezawa T, Hayashi S(2番目), Hirai Y(10番目)(全11名)
    • Journal Title

      Clin J Gastroenterol

      Volume: 5 Pages: 69-73

    • Peer Reviewed
  • [Journal Article] Phosphatidyl-ethanolamine of Helicobacter pylori functionc as asteroid-binding lipid in the assimilation of free cholesterol and 3β-hydroxl steroids into the bacterial cell membrane2012

    • Author(s)
      Shimomura H, Hosoda K, Hayashi S, Yokota K, Hirai Y
    • Journal Title

      J Bacteriol

      Volume: 194 Pages: 2658-2667

    • Peer Reviewed
  • [Journal Article] Steroid hormones as bactericidal agents to Helicobacter pylori2011

    • Author(s)
      Hosoda K, Shimomura H, Hayashi S, Yokota K, Hirai Y
    • Journal Title

      FEMS Microbiol lett

      Volume: 318 Pages: 68-75

    • Peer Reviewed
  • [Journal Article] New technique for direct percutaneous endoscopic jejunostomy using double-balloon endoscopy and magnetic anchors in a porcine model2011

    • Author(s)
      Yano T(1番目、全12名)
    • Journal Title

      Dig Endosc

      Volume: 23 Pages: 206

    • Peer Reviewed
  • [Journal Article] Helicobacter pyloriと胃癌2011

    • Author(s)
      下村裕史、林俊治、平井義一
    • Journal Title

      臨床と微生物

      Volume: 38 Pages: 195-202

  • [Journal Article] Helicobacter pyloriのほかにもヒト発癌との関連が示唆されている寄生生物はありますか2010

    • Author(s)
      林俊治、平井義一
    • Journal Title

      Helicobacter Research

      Volume: 14 Pages: 331-333

  • [Journal Article] Helicobacte pylori感染と免疫応答2010

    • Author(s)
      林俊治、下村裕史、平井義一
    • Journal Title

      臨床検査

      Volume: 54 Pages: 151-157

  • [Journal Article] Helicobacter pylori感染と胃内細菌叢2010

    • Author(s)
      林俊治、林芳和、平井義一
    • Journal Title

      Helicobacter Research

      Volume: 14 Pages: 39-43

  • [Journal Article] Steroid mediate resistance to the bactericidal effect of phosphatidyl-cholines against Helicobacter pylori2009

    • Author(s)
      Shimomura H、Hosoda K、Hayashi S(3番目)、Hirai Y(6番目)(全6名)
    • Journal Title

      FEMS Microbiol Lett

      Volume: 301 Pages: 84-94

    • Peer Reviewed
  • [Journal Article] Anabolic utilization of steroid hormones in Helicobacter pylori2009

    • Author(s)
      Hosoda K、Shimomura H(2番目)、Hayashi S(3番目)、Hirai Y(6番目)(全6名)
    • Journal Title

      FEMS Microbiol Lett

      Volume: 297 Pages: 173-179

    • Peer Reviewed
  • [Journal Article] Current state of double balloon endoscopy : the latest approach to small intestinal diseases2009

    • Author(s)
      Yano T、Yamamoto H
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 24 Pages: 185-92

    • Peer Reviewed
  • [Presentation] Clinical and microbiological studies on human intestinal spirochaetosis、International workshop2012

    • Author(s)
      Takezawa T, Hayashi S, Hirai Y, Sugano K
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-20
  • [Presentation] ヒトの胃と小腸の細菌叢、シンポジウム「消化管細菌叢」

    • Author(s)
      林俊治、林芳和、太田英孝、平井義一
    • Organizer
      第93回日本細菌学会関東支部総会
  • [Book] Clostridium difficile関連疾患2011

    • Author(s)
      林俊治
    • Total Pages
      184-186
    • Publisher
      南江堂
  • [Book] 病原性(下痢原性)大腸菌感染症2010

    • Author(s)
      平井義一
    • Total Pages
      460-463
    • Publisher
      医学書院

URL: 

Published: 2013-07-31  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi