2011 Fiscal Year Final Research Report
Development of immunotherapy and virotherapy against ATL
| Project/Area Number |
21590504
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Hokkaido University |
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Principal Investigator |
OHASHI Takashi 北海道大学, 遺伝子病制御研究所, 准教授 (10282774)
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| Project Period (FY) |
2009 – 2011
|
| Keywords | HTLV-I / 成人T細胞白血病 / 動物モデル / 免疫治療 / ウイルス療法 |
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| Research Abstract |
The potential for novel therapies against Human T-cell leukemia virus type I (HTLV-I) induced-adult T-cell leukemia (ATL) has been assessed in a rat model of HTLV-I infection. The results indicate that the single chain trimer (SCT) of MHC-I linked to HTLV-I epitope peptide is able to induce HTLV-I-specific cytotoxic responses and that LC16m8Δ, a highly attenuated vaccinia strain, has an ability to lyse HTLV-I-infected T cells. These results should be useful for further verifying the strategies to fight against HTLV-I.
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