2011 Fiscal Year Final Research Report
Development of anti-HIV agents for the viral variants
| Project/Area Number |
21590506
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
HOSHINO Tyuji 千葉大学, 大学院・薬学研究院, 准教授 (90257220)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 分子 / 阻害剤開発 |
|---|
| Research Abstract |
In order to produce the anti-HIV agents effective for the viral variants, we carried out in silico drug design, organic synthesis, and assay of the compound potency. The designed compounds were intended to be targeted on the I84V and V82A mutants of HIV-1 protease. Several compounds were synthesized, and some of the intermediates of the designed compounds showed anti-viral activity. It is required to enhance the compound potency greatly. Accordingly, the modification of the derivatives should be performed to produce a potent agent in our future work.
|
-
[Journal Article] Structural Modulation Study of Inhibitory Compounds for RN ase H Activity of HIV-1 Reverse Transcriptase2012
Author(s)
H. Yanagita, S. Fudo, E. Urano, R. Ichikawa, M. Ogata, M. Yokota, T. Murakami, H. Wu, J. Chiba, J. Komano, T. Hoshino
-
Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 60巻(印刷中)
Peer Reviewed
-
[Journal Article] Structural and Biochemical Study on the Inhibitory Activity of Derivatives of5-nitro-furan-2-carboxylic acid for RNase H Function of HIV-1 Reverse Transcriptase2011
Author(s)
H. Yanagita, E. Urano, K. Matsumoto, R. Ichikawa, Y. Takaesu, M. Ogata, T. Murakami, H. G. Wu, J. Chiba, J. Komano, T. Hoshino
-
Journal Title
Bioorganic Medicinal Chemistry
Volume: 19巻
Pages: 816-825
Peer Reviewed
-
-
-
