2011 Fiscal Year Final Research Report
Study of mechanism for the development of ATL and HAM by using HTLV-1 infected humanized mouse model
| Project/Area Number |
21590515
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | Kansai Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKUNOUCHI Norihiro 関西医科大学, 医学部, 准教授 (20533235)
TANAKA Masakazu 関西医科大学, 医学部, 助教 (20454613)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | HTLV-1 / ヒト化マウス / マウスモデル / ATL / NOG-SCID |
|---|
| Research Abstract |
By infecting HTLV-1 to humanized NOG-SCID mouse established by the intra-bone-marrow transplantation of human hematopoietic stem cells we successfully recapitulated the ATL-like phenotypes such as overgrowth of infected T cells, hepatosplenomegaly and induction of T lymphocytes with flower-shaped nuclei. Host immune system against HTLV-1 was established and the outgrowth of limited number of infected T cell clones was observed. In the course of clonal selection of infected T cells the expression of HTLV-1 Tax became silenced and the infected CD25-negative T cells were changed to express CD25.
|
