2011 Fiscal Year Final Research Report
Determination of biochemical characteristics for the host-defense factors, APOBEC 3, to reveal the mechanisms of anti-retroelement activities
| Project/Area Number |
21590525
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | National Hospital Organization Nagoya Medical Center |
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Principal Investigator |
IWATANI Yasumasa 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), 感染・免疫研究部, 室長 (90303403)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ウィルス / 生体分子 / 酵素 / 蛋白質 / 生体防御因子 |
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| Research Abstract |
The human APOBEC3 family(A, B, C, DE, F, G, and H) proteins are cellular defense factors that potently inhibit the replication of retroviruses, including HIV. In order to clarify the anti-viral mechanism, we determined the biochemical characteristics of the enzymes. Furthermore, we identified four ubiquitination sites of APOBEC3G that are critical for HIV Vif-mediated degradation. Our findings will provide important informationto further understand the molecular mechanisms of Anti-viral activities as well as to develop attractive strategies utilizing potential endogenous inhibitors against HIV.
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[Journal Article] Outbreak of hepatitis B virus genotypeA and transmission of genetic drug resistance in cases coinfected with HIV-1 in Japan2011
Author(s)
Fujisaki S, Yokomaku Y, Shiino T, Koibuchi T, Hattori J, Ibe S, Iwatani Y, Iwamoto A, Shirasaka T, Hamaguchi M, Sugiura W
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Journal Title
J. Clin. Microbiol
Volume: 49
Pages: 1017-1024
DOI
Peer Reviewed
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[Journal Article] Two geneticdeterminants acquired late in Mus evolution regulate the inclusion of exon5, which alters mouse APOBEC3 translation efficiency2011
Author(s)
Li, J., Hakata, Y., Takeda, E., Liu, Q., Iwatani, Y., Kozak, CA., and Miyazawa, M.
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Journal Title
PLoS Pathogens
Volume: 8
Pages: e1002478
DOI
Peer Reviewed
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[Journal Article] HIV-2 CRF01_AB : first circulating recombinant form of HIV-22010
Author(s)
Ibe S, Yokomaku Y, Shiino T, Tanaka R, Hattori J, Fujisaki S, Iwatani Y, Mamiya N, Utsumi M, Kato S, Hamaguchi M, Sugiura W.
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Journal Title
J. AIDS
Volume: 54
Pages: 241-247
DOI
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