2011 Fiscal Year Final Research Report
Signal transduction of TLR by STM/Hrs
| Project/Area Number |
21590527
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Iwaki Meisei University |
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Principal Investigator |
MURATA Kazuko いわき明星大学, 薬学部, 教授 (20137631)
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| Co-Investigator(Kenkyū-buntansha) |
SUGAMURA Kazuo 宮城県立がんセンター研究所, 特任部長 (20117360)
NAGATA Takayuki いわき明星大学, 薬学部, 助手 (50553202)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 自然免疫 |
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| Research Abstract |
We investigated the effects of STAM1/2 on innate immunity, in particular, on the degradation of Toll-like receptor(TLR) family members TLR4.STAMs may play an important role in the lysosomal degradation and translocation of TLR4 upon stimulation with LPS. These observations suggest that STAMs function as negative regulators of innate immunity mediated by TLR4.
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