2011 Fiscal Year Final Research Report
Identification of ubiquitin-dependent endosomal sorting signal in cytokine receptors
| Project/Area Number |
21590530
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOJIMA Katsuhiko 信州大学, 医学部, 助教 (80345743)
YOSHINO Kazuhisa 信州大学, 医学部, 助教 (40551859)
AMANO Yuji 信州大学, 医学部, 助教 (50624681)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 小胞輸送 |
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| Research Abstract |
In immune or nerve system, intracellular compartments maintain the function, which is supported by endosomal sorting, keeps the specific substances of the system and exchanges the substances between the compartments without physiological and morphological disorder. Here, we showed ubiquitin-independent endosomal sorting of interleukin-2 receptorβ(IL-2Rβ) and identified a novel endosomal sorting signal in the cytoplasmic region of IL-2Rβ. Our report provides the first description of endosomal sorting signal in a ubiquitin-independent manner.
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Research Products
(6 results)
