2012 Fiscal Year Final Research Report
Analysis of the transcriptional complexes containing Foxp3
| Project/Area Number |
21590533
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
OHKURA Naganari 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (20300949)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 制御性T細胞 / Foxp3 / transcriptional complex / 転写制御 |
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| Research Abstract |
Regulatory T (Treg) cells engage in the maintenance of immunological self-tolerance. The transcription factor Foxp3 has been recognized as a master regulator of Treg cells, yet the molecular mechanisms by which Foxp3 controls its target genes still remain elusive. By characterizing transcriptional complexes containing Foxp3, we found that the T cell-specific transcription factor Bcl11b and genome organizer Satb1 were important for exerting Treg functions. Bcl11b-deficient Treg cells lost suppressive activity, resulting in the development of severe autoimmune diseases. In Satb1-deficinet mice, Treg cells lost the Treg-specific DNA hypomethylation pattern. These results indicate that Bcl11b and Satb1 are essential constituents of Foxp3-containing complexes for exerting Treg-specific transcriptional regulation.
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[Journal Article] T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development2012
Author(s)
Ohkura N, Hamaguchi M, Morikawa H, Sugimura K, Tanaka A, Ito Y, Osaki M, Tanaka Y, Yamashita R, Nakano N, Huehn J, Fehling HJ, Sparwasser T, Nakai K, Sakaguchi S.
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Journal Title
Immunity
Volume: 37(5)
Pages: 785-99
Peer Reviewed
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[Journal Article] HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo.2011
Author(s)
Satou Y, Yasunaga J, Zhao T, Yoshida M, Miyazato P, Takai K, Shimizu K, Ohshima K, Green PL, Ohkura N, Yamaguchi T, Ono M, Sakaguchi S, Matsuoka M.
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Journal Title
PLoS Pathog
Volume: 7(2)
Pages: e1001274
Peer Reviewed
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[Journal Article] Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells.2009
Author(s)
Kitoh A, Ono M, Naoe Y, Ohkura N, Yamaguchi T, Yaguchi H, Kitabayashi I, Tsukada T, Nomura T, Miyachi Y, Taniuchi I, Sakaguchi S.
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Journal Title
Immunity.
Volume: 31(4)
Pages: 609-20
Peer Reviewed
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