2011 Fiscal Year Final Research Report
Aanalysis of immune activation and protective mechanisms against infection using agonistic anti-TLR4 mAb
| Project/Area Number |
21590538
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Saga University |
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Principal Investigator |
KIMOTO Masao 佐賀大学, 医学部, 教授 (40153225)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDOME Kenji 佐賀大学, 医学部, 准教授 (50284625)
TSUKAMOTO Hiroki 佐賀大学, 医学部, 助教 (70423605)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 抗体 / 免疫賦活 |
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| Research Abstract |
We analyzed the effects of agonistic anti-TLR4 mAb in vivo and in vitro. Anti-TLR4 agonistic mAb showed ajuvant effects in vivo. However, pre-injection of this agonistic mAb inhibited antibody production upon subsequent immunization. Cellular analysis revealed that this inhibitory effects was not due to the defect in antigen presentation to T cells but due to the defect in B cell priming. This finding will provide important information for the vaccine development and clinical use.
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[Journal Article] Arai H, Kadowaki T, Nagai R.: Saturated Fatty Acid and TLR Signaling LinkβCell Dysfunction and Islet Inflammation2012
Author(s)
Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, Nagai R.
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Journal Title
Cell Metab
Volume: (in press)
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[Journal Article] Endotoxin tolerance attenuates airway allergic inflammation in model mice by suppression of the T-cell stimulatory effect of dendritic cells2010
Author(s)
Matsushita H, Ohta S, Shiraishi H, Suzuki S, Arima K, Toda S, Tanaka H, Nagai H, Kimoto M, Inokuchi A, Izuhara K.
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Journal Title
Int Immunol
Volume: 22(9)
Pages: 739-47
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