The co-stimulatory effect of CD28 and ICOS on T cell response

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590541
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: Tokyo University of Science
• Principal Investigator: ABE Ryo 東京理科大学, 生命科学研究所, 教授 (20159453)
• Co-Investigator(Kenkyū-buntansha): OGAWA Shuhei 東京理科大学, 生命医科学研究所, 助教 (20385553)
• Project Period (FY): 2009 – 2011
• Keywords: 獲得免疫

Research Abstract

In this study, we examined the functional role of CD28 and ICOS-mediated costimulation in T cell responses using mutant CD28 and ICOS transgenic mice.

Research Products

• [Journal Article] The transcription factor AP-1 is involved in ICOS gene expression downstream of TCR/CD28 signaling and cytokine receptor signaling (2012)
  • Author(s): Watanabe M, Nakajima S, Kazunobu O, Ogawa S, Yamashita M, Nakayama T, Murakami Y, Tanabe K, Abe R
  • Journal Title: Eur J Immunol
  • DOI: doi:10.1002/eji.201141897.
  • Peer Reviewed
• [Journal Article] Amelioration of cardiac allograft deterioration by interleukin-6 receptor signaling disruption in mice (2012)
  • Author(s): Iida S, Omoto K, Kanemitsu I, Setoguchi K, Ishida H, Tanabe K, Suzuki T, Tashiro Y, Kishimoto H, Abe R
  • Journal Title: Experimental and Clinical transplantation
  • Peer Reviewed
• [Journal Article] Ex vivo-expanded DCs induce donor-specific central and peripheral tolerance and prolong the acceptance of donor skin grafts (2011)
  • Author(s): Yamano T, Watanabe S, Hasegawa H, Suzuki T, Abe R, Tahara H, Nitta T, Ishimaru N, Sprent J, Kishimoto H
  • Journal Title: Blood Volume: 117(9) Pages: 2640-8
  • Peer Reviewed
• [Journal Article] Potential role of host effector memory CD8+T cells in marrow rejection after mixed chimerism induction in cynomolgus monkeys (2010)
  • Author(s): Setoguchi K, Kishimoto H, Kobayashi S, Shimmura H, Ishida H, Toki D, Suzuki T, Ohnuki K, Tate Y, Fujioka S, Abe R, Tanabe K
  • Journal Title: Transpl Immunol Volume: 23(4) Pages: 194-203
  • Peer Reviewed
• [Journal Article] Suppression of Con A-induced hepatitis induction in ICOS-deficient mice (2009)
  • Author(s): Watanabe S, Ohnuki K, Hara Y, Ishida Y, Ikarashi Y, Ogawa S, Kishimoto H, Tanabe K, Abe R
  • Journal Title: Immunol Lett
  • Peer Reviewed
• [Presentation] The functional relationship between CD28 YMNM and PxxP motifs in CD28-mediated costimulation (2011)
  • Author(s): Ogawa S., Sakurai Y., Katayama A., Shigeta M., Yoshida N., Horibe C., Gamoh S., Ohtsuka S., Maruyama H., Iida M., Hiruta T., and Abe R.
  • Organizer: 第40回日本免疫学会総会
  • Year and Date: 20111127-29
• [Presentation] Different requirements for induction of the CD28-mediated signal transduction pathway in naive vs activated T cells (2010)
  • Author(s): Ogawa S., Watanabe S., Inutake Y., Sakurai Y., Katayama A., and Abe R.
  • Organizer: 14^<th> International Congress of Immunology
  • Year and Date: 20100823-27
• [Presentation] The effect of CD28 mediated costimulation in response of naive and memory T cells (2009)
  • Author(s): Ogawa S., Inutake Y., Sakurai Y., Miura Y., Katayama A., Higo K., Watanabe S., Kishimoto H., Abe R
  • Organizer: 第39回日本免疫学会総会
  • Year and Date: 20091202-04
• [Book] 免疫力アップジュース (2011)
  • Author(s): 安部良、大越郷子
  • Publisher: (株)西東社
• [Remarks]
  • URL: http://www.rs.noda.sut.ac.jp/～immunol/index.html