2011 Fiscal Year Final Research Report
Evaluation of dendritic cells(DCs) in the regulation of memory T cells
| Project/Area Number |
21590546
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
FUJII Shin-ichiro 独立行政法人理化学研究所, 免疫細胞移植戦略研究ユニット, ユニットリーダー (10392094)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 記憶免疫 / 自然免疫 / 樹状細胞 / NKT細胞 |
|---|
| Research Abstract |
To induce not only effector T cells, but also memory T cells is important issue for an establishment of immune defense against infectious and cancer diseases. There are many reports of memory T cells in some viral infectious diseases, however to induce anti-tumor T cell effects against tumor associated antigen has not been studied well, due to the low amounts of antigen expression on tumor cells. We previously demonstrated that our strategy using NKT ligand loaded tumor cells showed long term antitumor effects. In the current study, we analyzed the kinetics of memory T cells and elucidated the mechanism of the induction of memory T cells.
|
-
-
-
-
-
[Journal Article] Efficient cross-presentation of soluble exogenous antigens introduced into dendritic cells using a weak-based amphiphilic peptide2010
Author(s)
Ikeuchi N, Futami J, Hosoi A, Noji S, Kurachi M, Ueha S, Fujii S, Yamada H, Matsushima K, Moriyasu F, Kakimi K
-
Journal Title
Biochem Biophys Res Commun
Volume: 392
Pages: 217-22
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] A set of genes associated with the IFN-γresponse and survival undergoing NKT cell-based immunotherapy2010
Author(s)
Ishibashi F, Motohashi S, Okita K, Yamasaki K, Nagato K, Hijikata A, Kitamura H, Fujii S, Taniguchi M, Ohara O, Nakayama T
Organizer
14th International Congress of Immunology
Place of Presentation
Kobe
Year and Date
20100822-27
-
[Presentation] Reprogramming of natural killer T(NKT) cells to induced pluripotent stem cells and their development into functional NKT cells in vitro2010
Author(s)
Watarai H, Fujii S, Yamada D, Rybouchkin A, Nagata Y, Iida-Kobayashi M, Kondo E, Shimizu K, Endo T, Toyoda T, Ohara O, Koseki H, Taniguchi M
Organizer
14th International Congress of Immunology
Place of Presentation
Kobe
Year and Date
20100822-27
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
