2011 Fiscal Year Final Research Report
Elucidation of the mechanisms in the regulation of type I interferon production in plasmacytoid dendritic cells
| Project/Area Number |
21590547
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
WATARAI Hiroshi 独立行政法人理化学研究所, 免疫制御研究グループ, 上級研究員 (70415339)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 形質細胞様樹状細胞 / インターフェロン / 生体防御 / ウイルス / Toll様受容体 / プレキシン / セマフォリン |
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| Research Abstract |
Plasmacytoid dendritic cells(PDC) play a pivotal role in host defense against viruses by their robust production of type I interferons. They exclusively express TLR7 and TLR9 which is a sensor to viral and microbial DNA and RNA, while it has still been unclear in the mechanisms in the augmentation and regulation of cytokine productions. In this research, PDC-TREM, a specific surface receptor on activated PDC surface, has been investigated. PDC-TREM is associated with PlxnA1, a ligand for Sema6D, and gives signals through adaptor molecule DAP12, resulting in the regulation of type I IFN production.
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[Journal Article] RCAI-39, 41, 53, 100, 127 and 128, the analogues of KRN7000, activate mouse natural killer T cells to produce Th2-biased cytokines by their administration as liposomal particles2011
Author(s)
Tashiro T, Ishii Y, Shigeura T, Nakagawa R, Watarai H, Taniguchi M, Mori K.
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Journal Title
Med Chem Comm
Volume: 2
Pages: 620-625
Peer Reviewed
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[Journal Article] E4bp4, a mammalian basic leucine zipper transcriptinal factor, is a critical regulator of IL-10 and IL-13 production by CD4 T cells2011
Author(s)
Motomura Y, Kitamura H, Hijikata A, Matsunaga Y, Matsumoto K, Inoue H, Atarashi K, Hori S, Watarai H, Zhu J, Taniguchi M, Kubo M.
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Journal Title
Nat Immunol
Volume: 12(5)
Pages: 450-459
Peer Reviewed
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[Journal Article] Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells2010
Author(s)
Watarai H, Fujii SI, Yamada D, Rybouchkin A, Sakata S, Nagata Y, Iida-Kobayashi M, Sekine-Kondo E, Shimizu K, Shozaki Y, Sharif J, Matsuda M, Mochiduki S, Hasegawa T, Kitahara G, Endo T, Toyoda T, Ohara O, Harigaya KI, Koseki H, Taniguchi M.
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Journal Title
J Clin Invest
Volume: 120(7)
Pages: 2610-2618
Peer Reviewed
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[Journal Article] Induction of Th1-biased cytokine production byα-carba-GalCer, a neoglycolipid ligand for natural killer T cells2010
Author(s)
Tashiro T, Sekine-Kondo E, Shigeura T, Nakagawa R, Inoue S, Omori-Miyake M, Chiba T, Hongo N, Fujii SI, Shimizu K, Mori K, Yoshiga Y, Sumida T, Watarai H, Taniguchi M.
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Journal Title
Int Immunol
Volume: 22(4)
Pages: 319-328
Peer Reviewed
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[Journal Article] High-mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice2010
Author(s)
Matsuoka N, Itoh T, Watarai H, Sekine-Kondo E, Nagata N, Okamoto K, Mera T, Yamamoto H, Yamada S, Maruyama I, Taniguchi M, Yasunami Y.
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Journal Title
J Clin Invest
Volume: 120(3)
Pages: 735-743
Peer Reviewed
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[Journal Article] Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Vα14-Jα18 TCRαgene2010
Author(s)
Watarai H, Rybouchkin A, Hongo N, Nagata Y, Sakata S, Sekine E, Dashtsoodol N, Tashiro T, Fujii SI, Shimizu K, Mori K, Masuda K, Kawamoto H, Koseki H, Taniguchi M.
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Journal Title
Blood
Volume: 115(2)
Pages: 230-237
Peer Reviewed
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[Journal Article] M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex2009
Author(s)
Hase K, Kimura S, Takatsu H, Ohmae M, Kawano S, Kitamura H, Ito M, Watarai H, Hazelett CC, Yeaman C, Ohno H.
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Journal Title
Nat Cell Biol
Volume: 11(12)
Pages: 1427-1432
Peer Reviewed
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[Journal Article] RCAI-37, 56, 59, 60, 92, 101, and 102, cyclitol and carbasugar analogs of KRN7000 : their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines2009
Author(s)
Tashiro T, Nakagawa R, Hirokawa T, Inoue S, Watarai H, Taniguchi M, Mori K.
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Journal Title
Bioorgan Med Chem
Volume: 17(17)
Pages: 6360-6373
Peer Reviewed
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[Presentation] Reprogramming of natural killer T(NKT) cells to induced pluripotent stem cells and their development into functional NKT cells in vitro2010
Author(s)
Watarai H, Fujii S, Yamada D, Rybouchkin A, Sakata S, Nagata Y, Iida-Kobayashi M, Sekine-Kondo E, Shimizu K, Endo TA, Toyoda T, Ohara O, Koseki H, Taniguchi M.
Organizer
16^<th> International Conference of the International Society of Differentiation
Place of Presentation
Nara, Japan
Year and Date
2010-11-16
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[Presentation] Reprogramming of natural killer T(NKT) cells to induced pluripotent stem cells and their development into functional NKT cells in vitro2010
Author(s)
Watarai H, Fujii S, Yamada D, Rybouchkin A, Sakata S, Nagata Y, Iida-Kobayashi M, Sekine-Kondo E, Shimizu K, Endo TA, Toyoda T, Ohara O, Koseki H, Taniguchi M.
Organizer
14^<th> International Congress on Immunology
Place of Presentation
Kobe, Japan
Year and Date
2010-08-23
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