2011 Fiscal Year Final Research Report
Mechanisms of T cell activation regulation by inhibitory microclusters
| Project/Area Number |
21590548
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YOKOSUKA Tadashi 独立行政法人理化学研究所, 免疫シグナル研究グループ, 上級研究員 (10359599)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 免疫学 / シグナル伝達 / 分子イメージング / T細胞受容体 / 補助刺激受容体 |
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| Research Abstract |
Imaging analysis of the negative costimulatory receptor, CTLA-4, revealed the novel mechanism of T cell activation regulation. CTLA-4 formed clusters at the center of the immunological synapse and interfered the formation of the signaling molecule complex, which is composed by the positive costimulatory receptor CD28, kinases, and scaffold proteins. These results suggest that T cell activation is cooperatively regulated by both T cell receptor. CD28 microclusters and the CTLA-4-mediated inhibitory microclusters.
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Research Products
(42 results)
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[Journal Article] CRTAM confers late-stage activation of CD8+T cells to regulate retention within lymph node2009
Author(s)
Takeuchi A, Itoh Y, Takumi A, Ishihara C, Arase N, Yokosuka T, Koseki H, Yamasaki S, Takai Y, Miyoshi J, Ogasawara K, Saito T.
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Journal Title
J Immunol
Volume: 183(7)
Pages: 4220-4228
Peer Reviewed
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