2011 Fiscal Year Final Research Report
Development of monoclonal antibodies therapy for cerebral infarction and cerebral edema
| Project/Area Number |
21590594
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Okayama University |
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Principal Investigator |
RYU Katsuyaku 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40432637)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIBORI Masahiro 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50135943)
WAKE Hidenori 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60570520)
TAKAHASHI Hideo 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (60335627)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脳梗塞 / 脳浮腫 / 抗体医薬 / 血液脳関門 / 炎症 / HMGB1 |
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| Research Abstract |
High mobility group box1(HMGB1) originally identified as an architectural nuclear protein exhibits an inflammatory cytokine-like activity in the extracellular space. We showed that treatment with anti-HMGB1 monoclonal antibody(mAb) remarkably ameliorated brain infarction and edema induced by 2-hours middle cerebral artery occlusion(MCAO) in rats, even when the mAb was administered after reperfusion. Our results indicated that anti-HMGB1 mAb efficiently inhibited the development of brain edema through the protection of blood-brain barrier(BBB) structure in the ischemic region.
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[Journal Article] Anti-high mobility group box-1 monoclonal antibody protects the blood-brain barrier from ischemia-induced disruption in rats2011
Author(s)
Zhang J, Takahashi HK, Liu K, Wake H, Liu R, Maruo T, Date I, Yoshino T, Ohtsuka A, Mori S, Nishibori M
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Journal Title
Stroke
Volume: 42(5)
Pages: 1420-8
Peer Reviewed
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[Journal Article] High-mobility group box protein 1 neutralization reduces development of diet-induced atherosclerosis in apolipoproteine-deficient mice2011
Author(s)
Kanellakis P, Agrotis A, Kyaw TS, Koulis C, Ahrens I, Mori S, Takahashi HK, Liu K, Peter K, Nishibori M, Bobik A
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 31(2)
Pages: 313-9
Peer Reviewed
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[Journal Article] Prostaglandin E2 inhibits advanced glycation end product induced adhesion molecule expression on monocytes, cytokine production, and lymphocyte proliferation during human mixed lymphocyte reaction2010
Author(s)
Takahashi HK, Zhang J, Mori S, Liu K, Wake H, Liu R, Sadamori H, Matsuda H, Yagi T, Yoshino T, Nishibori M
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Journal Title
J Pharmacol Exp Ther
Volume: 34(3)
Pages: 964-72
Peer Reviewed
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[Journal Article] Advanced glycation end products enhance monocyte activation during human mixedlymphocyte reaction2010
Author(s)
Ohashi K, Takahashi HK, Mori S, Liu K, Wake H, Sadamori H, Matsuda H, Yagi T, Yoshino T, Nishibori M, Tanaka N
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Journal Title
Clin Immunol
Volume: 134(3)
Pages: 345-53
Peer Reviewed
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