Optimization of antifungal regimens based on site-specific pharmacokinetics-pharmacodynamics-pharmacogenomics

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590595
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Hiroshima University
• Principal Investigator: IKAWA Kazuro 広島大学, 大学院・医歯薬学総合研究科, 准教授 (40363048)
• Co-Investigator(Kenkyū-buntansha): MORIKAWA Norifumi 広島大学, 大学院・医歯薬学総合研究科, 教授 (30346481) ; IKEDA Kayo 広島大学, 大学院・医歯薬学総合研究科, 助教 (30379911)
• Project Period (FY): 2009 – 2011
• Keywords: 臨床 / 感染症 / 薬物動態 / 薬力学

Research Abstract

The present research established simple and rapid systems to determine drug concentrations for azole and candin antifungals. The research performed pharmacokinetic analyses of drug concentration data, which were obtained by measuring concentrations in plasma and biological fluids, at the target sites, of patients. Then, the research examined the relationship between pharmacokinetics and pharmaco dynamics by incorporating pharmacogenomic data(wild type, mutant heterozygous or homozygous mutant of P450) as covariates. By Monte Carlo simulation with this modeling, the research investigated the optimal antifungal regimens. Also, the research developed software technology that healthcare professionals can design the optimal antifungal regimens based on information about the patient and causative bacteria.

Research Products

• [Journal Article] メロペネムPK-PDソフトウェアを用いた個別的適正投与設計 (2012)
  • Author(s): 石原慎之, 西村信弘, 陶山登之, 玉木宏樹, 神田響, 礒部威, 猪川和朗, 森川則文, 直良浩司
  • Journal Title: TDM研究 Volume: 29 Pages: 53-60
  • Peer Reviewed
• [Journal Article] Safety analysis of liposomal amphotericin B in adult patients : anaemia, thrombocytopenia, nephrotoxicity, hepatotoxicity and hypokalaemia (2011)
  • Author(s): Shigemi A, Matsumoto K, Ikawa K, YajiK, Shimodozono Y, Morikawa N, TakedaY, Yamada K.
  • Journal Title: Int. J. Antimicrob. Agents Volume: 38 Pages: 417-420
  • Peer Reviewed
• [Journal Article] 母集団PGx-PK-PD解析による抗真菌薬の個別的至適投与 (2011)
  • Author(s): 猪川和朗
  • Journal Title: 臨床薬理 Volume: 42 Pages: 129S. 129S
• [Journal Article] Assessment of micafungin regimens by pharmacokinetic-pharmacodynamic analysis : a dosing strategy for Aspergillus infections (2009)
  • Author(s): Ikawa K, Nomura K, Morikawa N, IkedaK, Taniwaki M.
  • Journal Title: J. Antimicrob. Chemother Volume: 64 Pages: 840-844
  • Peer Reviewed
• [Journal Article] Correlation between voriconazole trough plasma concentration and hepatotoxicity inpatients with different CYP2C19 genotypes (2009)
  • Author(s): Matsumoto K, Ikawa K, Abematsu K, Fukunaga N, Nishida K, Fukamizu T, Shimodozono Y, Morikawa N, Takeda Y, Yamada K.
  • Journal Title: Int. J. Antimicrob. Agents Volume: 34 Pages: 91-94
  • Peer Reviewed
• [Presentation] PK-PDソフトウェアを用いたdoripenemの個別的至適投与の取り組み (2011)
  • Author(s): 西村信弘, 石原慎之, 狩野芙美, 礒部威, 猪川和朗, 森川則文
  • Organizer: 第54回日本感染症学会中日本地方会学術集会・第59回日本化学療法学会西日本支部総会
  • Place of Presentation: 奈良
  • Year and Date: 2011-11-24
• [Presentation] アムホテリシンBリポソーム製剤による血液毒性の評価-投与量依存的に発現する貧血と血小板減少症- (2011)
  • Author(s): 松元一明, 茂見茜里, 猪川和朗, 森川則文, 屋地慶子, 下堂薗権洋, 武田泰生, 山田勝士
  • Organizer: 第59回日本化学療法学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2011-06-24
• [Presentation] カンジダ感染症およびアスペルギルス感染症に対するミカファンギン投与法のPK-PD評価 (2010)
  • Author(s): 門川千夏, 猪川和朗, 野村憲一, 池田佳代, 森川則文, 谷脇雅史
  • Organizer: 第27回日本TDM学会学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-27
• [Presentation] アムホテリシンBおよびバンコマイシン含有骨セメントから血中への薬物放出動態:症例検討 (2010)
  • Author(s): 今井友香梨, 猪川和朗, 菅麻弓美, 小澄俊博, 坪島愛, 池田佳代, 森川則文, 森生美和, 堀川俊二, 金沢敏勝
  • Organizer: 第27回日本TDM学会学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-26
• [Presentation] Dexamethasone reduced voricona zoleplasma level in a patient who carries CYP2C19 mutant (2009)
  • Author(s): Matsumoto K, Kondo T, Kanazawa N, Yokoyama Y, Fukamizu T, Takeda Y, Mukai M, Arimura H, Nakazaki M, IkawaK, Morikawa N, Tei C, Yamada K.
  • Organizer: Asian Federation for Pharmaceutical Sciences 2009
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2009-10-16
• [Presentation] Considerations ofmicafungin regimen for Candida andAspergillus infections based onpharmacokinetic-pharmacody namictarget attainment analysis (2009)
  • Author(s): Ikawa K, Nomura K, Morikawa N, IkedaK, Taniwaki M
  • Organizer: 49th Interscience Conference on Antimicrobial Agents and Chemotherapy
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2009-09-13