2011 Fiscal Year Final Research Report
INVESTIGATION OF THERAPEUTIC TARGET MOLECULES FOR ATRIAL FIBRILLATION REGULATING ELECTRICAL EXCITATION IN PULMONARY VEIN
| Project/Area Number |
21590602
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAMEKATA Iyuki 東邦大学, 薬学部, 講師 (30510309)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 心房細動 / 肺静脈 / 異常自動能 / 撃発活動 / 活動電位 / カルバコール / 抗不整脈薬 |
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| Research Abstract |
To clarify electrophysiological properties of the pulmonary vein(PV), we assessed its electrical activity and responses to drugs affecting intracellular Ca^<2+> concentration or ion-channel functions, which were compared with those in the atrium. In this study, triggered activity was induced by train stimulation in the PV, which was not observed in the left atrium. It is presumed that the less negative resting membrane potential in the PV cardiomyocytes induced Ca^<2+> overload during train stimulation, leading to generation of triggered activity. Activation of muscarinic receptors or GIRK channels, which could hyperpolarize the resting membrane potential of the PV, may become a pharmaceutical molecular target for strong suppression of the generation of triggered activity.
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[Journal Article] Asymmetric synthesis and biological evaluations of(+)-and(-)-6-dimethoxymethyl-1, 4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels2011
Author(s)
Yamamoto T, Ohno S, Niwa S, Tokumasu M, Hagiwara M, Koganei H, Fujita S, Takeda T, Saitou Y, Iwayama S, Takahara A, Iwata S, Shoji M.
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Journal Title
Bioorg. Med. Chem. Lett
Volume: 21(11)
Pages: 3317-3319
DOI
Peer Reviewed
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[Journal Article] Inhibitory effects of S(+)-efonidipine on the rabbit sinus node action potential and calcium channel subunits CaV1.2, CaV1.3 and CaV3.12010
Author(s)
Tanaka H, Namekata I, Ogawa T, Tsuneoka Y, Komikado C, Takahara A, Iida-Tanaka N, Izumi-Nakaseko H, Tsuru H, Adachi-Akahane S
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Journal Title
Eur. J. Pharmacol
Volume: 649(1-3)
Pages: 263-267
DOI
Peer Reviewed
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