2011 Fiscal Year Final Research Report
Significance of the vasoactive substances and interaction between inflammation and coagulation in DIC
| Project/Area Number |
21590614
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | DIC / 血管作動性物質 / サイトカイン |
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| Research Abstract |
We investigated the effect of erythropoietin, carbon monoxide release molecule and SnPP that may be able to interrupt interaction between coagulation and inflammation, on LPS-induced rat DIC model. The estimated markers were blood coagulation, fibrinolysis, organ injury, vasoactive substances, pathological findings and the mRNA expression of hemostatic substances. Although the effect of these drugs were different among doses or organs, such drugs without the influence on coagulation and fibrinolysis were expected as new DIC drugs.
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