Study on early diagnosis of hypercoagulable state and mechanism for the onset in thrombosis

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590623
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Mie University
• Principal Investigator: WADA Hideo 三重大学, 大学院・医学系研究科, 准教授 (40158704)
• Project Period (FY): 2009 – 2011
• Keywords: 血栓症 / 過凝固症 / 播種性血管内凝固 / 深部静脈血栓症 / 肺塞栓症 / 可溶性フィブリン / D-dimer

Research Abstract

Elevated hemostatic molecular markers and decreased anticoagulant factors are observed in the onset of thrombosis, thus suggesting that these markers are useful for both making diagnosis of thrombosis and predicting the outcome or efficacy of treatment. Not only hereditary deficiencies of anticoagulant factor such as protein S Tokushima but also secondary deficiencies of anticoagulant factor are frequently observed in the patients with thrombosis. Data from the monitoring of anticoagulant therapy suggest that elevated fibrinolysis may be more important than the anti-Xa activity for assessing major bleeding.

Research Products

• [Journal Article] Frequent association of thrombophilia in cerebral venous sinus thrombosis (2012)
  • Author(s): Ikejiri M, Shindo A, Ii Y, Tomimoto H, Yamada N, Matsumoto T, Abe Y, Nakatani K, Nobori T, Wada H.
  • Journal Title: Int J Hematol Volume: 95 Pages: 257-262
  • Peer Reviewed
• [Journal Article] Increased fibrinolysis increases bleeding in orthopedic patients receiving prophylactic fondaparinux (2012)
  • Author(s): Yoshida K, Wada H, Hasegawa M, Wakabayashi H, Matsumoto T, Shimokariya Y, Noma K, Yamada N, Uchida A, Nobori T, Sudo A.
  • Journal Title: Int J Hematol Volume: 95 Pages: 160-166
  • Peer Reviewed
• [Journal Article] A novel protein S gene mutation combined with protein S Tokushima mutation in a patient with superior sagittal sinus thrombosis (2012)
  • Author(s): Shindo A, Ikejiri M, Ii Y, Nakatani K, Wada H, Nobori T, Tomimoto H.
  • Journal Title: J Neurol Volume: 259 Pages: 178-9
  • Peer Reviewed
• [Journal Article] Plasma ADAMTS13, von Willebrand Factor(VWF) and VWF Propeptide Profiles in Patients with DIC and Related Diseases (2011)
  • Author(s): Habe K, Wada H, Ito-Habe N, Hatada T, Matsumoto T, Ohishi K, Maruyama K, Imai H, Mizutani H, Nobori T
  • Journal Title: Thromb Res. Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Monitoring for anti-Xa activity for prophylactic administration of fondaparinux in patients with artificial joint replacement (2011)
  • Author(s): Yoshida K, Wada H, Hasegawa M, Wakabayashi H, Ando H, Oshima S, Matsumoto T, Shimokariya Y, Noma K, Yamada N, Uchida A, Nobori T, Sudo A
  • Journal Title: Int J Hematol Volume: 94 Pages: 355-360
  • Peer Reviewed
• [Journal Article] High Plasma Level of Factor VIII (2011)
  • Author(s): Ota S, Yamada N, Ogihara Y, Tsuji A, Ishikura K, Nakamura M, Wada H, Ito M
  • Journal Title: Circ J Volume: 75 Pages: 1472-1475
  • Peer Reviewed
• [Journal Article] Japanese Society of Thrombosis Hemostasis/DIC subcommittee. Prospective evaluation of hemostatic abnormalities in overt DIC due to various underlying diseases (2011)
  • Author(s): Kawasugi K, Wada H, Hatada T, Okamoto K, Uchiyama T, Kushimoto S, Seki Y, Okamura T, Nobori T
  • Journal Title: Thromb Res Volume: 128 Pages: 186-90
  • Peer Reviewed
• [Journal Article] Katayama N Elevated Von Willebrand factor propeptide for the diagnosis of thrombotic microangiopathy and for predicting a poor outcome (2011)
  • Author(s): Ito-Habe N, Wada H, Matsumoto T, Ohishi K, Toyoda H, Ishikawa E, Nomura S, Komada Y, Ito M, Nobori T
  • Journal Title: Int J Hematol Volume: 93 Pages: 47-52
  • Peer Reviewed
• [Journal Article] Prospective evaluation of three different diagnostic criteria for disseminated intravascular coagulation (2011)
  • Author(s): Takemitsu T, Wada H, Hatada T, Ohmori Y, Ishikura K, Takeda T, Sugiyama T, Yamada N, Maruyama K, Katayama N, Isaji S, Shimpo H, Kusunoki M, Nobori T
  • Journal Title: Thromb Haemost Volume: 105 Pages: 40-44
  • Peer Reviewed
• [Journal Article] Japanese Society of Thrombosis Hemostasis/DIC subcommittee.: Modified non-overt DIC diagnostic criteria predict the early phase of overt-DIC (2010)
  • Author(s): Wada H, Hatada T, Okamoto K, Uchiyama T, Kawasugi K, Mayumi T, Gando S, Kushimoto S, Seki Y, Madoiwa S, Okamura T, Toh CH
  • Journal Title: Am J Hematol Volume: 85 Pages: 691-694
  • Peer Reviewed
• [Journal Article] The association of protein S Tokushima-K196E with a risk of deep vein thrombosis (2010)
  • Author(s): Ikejiri M, Wada H, Sakamoto Y, Ito N, Nishioka J, Nakatani K, Tsuji A, Yamada N, Nakamura M, Ito M, Nobori T
  • Journal Title: Int J Hematol Volume: 92 Pages: 302-305
  • Peer Reviewed
• [Journal Article] A second national questionnaire survey of TMA (2010)
  • Author(s): Ito-Habe N, Wada H, Matsumoto M, Fujimura Y, Murata M, Izuno T, Sugita M, Ikeda Y
  • Journal Title: Int J Hematol Volume: 92 Pages: 68-75
  • Peer Reviewed
• [Journal Article] Prevention of venous thromboembolism according to the guidelines of a domestic manual (2010)
  • Author(s): Kaneko T, Wada H, Nobori T, Yamada N, Nakamura M, Ito M
  • Journal Title: Int J Hematol Volume: 91 Pages: 909-911
  • Peer Reviewed
• [Journal Article] Elevated Fibrin-Related Markers in Patients with Malignant Diseases Suspected of Having Thrombotic Disorders (2010)
  • Author(s): Nomura H, Wada H, Mizuno T, Yamashita Y, Saito K, Kitano S, Katayama N, Yamada N, Sugiyama T, Sudo A, Usui M, Isaji S, Nobori T
  • Journal Title: Clin Appl Thromb Hemost Volume: 16 Pages: 266-272
  • Peer Reviewed
• [Journal Article] Evaluation of modified non-overt DIC criteria on the prediction of poor outcome in patients with sepsis (2010)
  • Author(s): Oh D, Jang MJ, Lee SJ, Chong SY, Kang MS, Wada H
  • Journal Title: Thromb Res Volume: 126 Pages: 18-23
  • Peer Reviewed
• [Journal Article] Japanese Society of Thrombosis Hemostasis/DIC subcommittee : Frequency and hemostatic abnormalities in pre-DIC patients (2010)
  • Author(s): Okamoto K, Wada H, Hatada T, Uchiyama T, Kawasugi K, Mayumi T, Gando S, Kushimoto S, Seki Y, Madoiwa S, Asakura H, Koga S, Iba T, Maruyama I
  • Journal Title: Thromb Res Volume: 126 Pages: 74-78
  • Peer Reviewed
• [Journal Article] Analysis three abnormal Protein S genes in a patient with pulmonary embolism (2010)
  • Author(s): Ikejiri M, Tsuji A, Wada H, Sakamoto Y, Nishioka J, Ota S, Yamada N, Matsumoto T, Nakatani K, Nobori T, Itoh M
  • Journal Title: Thromb Res Volume: 125 Pages: 529-532
  • Peer Reviewed
• [Journal Article] National questionnaire survey of TMA (2009)
  • Author(s): Ito N, Wada H, Matsumoto M, Fujimura Y, Murata M, Izuno T, Sugita M, Ikeda Y
  • Journal Title: Int J Hemato Volume: 90 Pages: 328-335
  • Peer Reviewed
• [Journal Article] Decreased ADAMTS13 Levels in Patients after Living Donor Liver Transplantation (2009)
  • Author(s): Kobayashi T, Wada H, Usui M, Sakurai H, Matsumoto T, Nobori T, Katayama N, Uemoto S, Ishizashi H, Matsumoto M, Fujimura Y, Isaji S
  • Journal Title: Thromb Res Volume: 124 Pages: 541-5
  • Peer Reviewed
• [Journal Article] Cut-off values of D-dimer and soluble fibrin for prediction of deep vein thrombosis after orthopaedic surgery (2009)
  • Author(s): Sudo A, Wada H, Nobori T, Yamada N, Ito M, Niimi R, Hasegawa M, Suzuki K, Uchida A
  • Journal Title: Int J Hematol Volume: 89 Pages: 572-576
  • Peer Reviewed
• [Presentation] Quantitative analysis of the domain-specific autoantibodies to ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura (2011)
  • Author(s): Igari A, Moriki T, Yamaguchi Y, Nakagawa T, Wada H, Matsumoto M, Fujimura Y, Soejima K, Murata M
  • Organizer: The 53th Annual Meeting of The American Society of Hematology
  • Place of Presentation: San Diego
  • Year and Date: 20111210-13
• [Presentation] 血栓・止血異常症診療センターの役割について (2011)
  • Author(s): 和田英夫
  • Organizer: 第21回日本臨床検査専門医会春季大会
  • Place of Presentation: 岩手アイーナ
  • Year and Date: 20110610-11
• [Presentation] Change of behavior in C4B binding protein and protein S in the patient with inflammatory disease (2011)
  • Author(s): Ikejiri M, Nishioka J, Sakamoto Y, Shimokariya Y, Noma K, Abe Y, Nakatani K, Wada H, Hayashi T, Suzuki K, Nobori T
  • Organizer: XXIIIth ISTH Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2011-07-25
• [Presentation] 血栓症の臨床up-to-date、シンポジウムIII「血栓症高まる検査の役割」 (2010)
  • Author(s): 和田英夫
  • Organizer: 第42回日本臨床検査自動化学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 20101007-09
• [Presentation] DICの新しい概念と治療への展望～臨床検査部の立場から～、シンポジウム「DIC治療の新しい展開～リコモジュリン製剤の登場～」 (2010)
  • Author(s): 和田英夫
  • Organizer: 第11回日本検査血液学会学術集会
  • Place of Presentation: 東京ビッグサイト
  • Year and Date: 20100724-25
• [Presentation] 日本血栓止血学会プロスペクティブスタディの解析報告、日本救急医学会ジョイントシンポジウム「DIC-診断と治療の最前線-」 (2010)
  • Author(s): 畑田剛、和田英夫
  • Organizer: 第33回日本血栓止血学会学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 20100422-24
• [Presentation] 静脈血栓塞栓症におけるフィブリン関連マーカーの有用性の検討 (2010)
  • Author(s): 和田英夫
  • Organizer: 第5回日本血栓止血学会学術標準化委員会シンポジウム(DIC部会)
  • Place of Presentation: 東医会館
  • Year and Date: 2010-10-30
• [Presentation] プロスペクティブスタデイの解析結果からのDIC診断における止血系マーカーの評価 (2010)
  • Author(s): 和田英夫
  • Organizer: 第5回日本血栓止血学会学術標準化委員会シンポジウム(DIC部会)
  • Place of Presentation: 東医会館
  • Year and Date: 2010-10-30
• [Presentation] Chairperson's repot (2010)
  • Author(s): Wada H
  • Organizer: 57th SSC meeting subcommittee for DIC
  • Place of Presentation: Kyoto
  • Year and Date: 2010-07-24
• [Presentation] Chairman's report (2010)
  • Author(s): Wada H
  • Organizer: 56th SSC meeting subcommittee for DIC
  • Place of Presentation: Cairo
  • Year and Date: 2010-05-24
• [Presentation] the Japanese guideline on DIC treatment (2010)
  • Author(s): Wada H
  • Organizer: 56th SSC meeting subcommittee for DIC
  • Place of Presentation: Cairo
  • Year and Date: 2010-05-24
• [Book] 臨床病理レビュー 特集第147号 DIC-とびらを拓く第三世代へ-臨床病理刊行会 (2011)
  • Author(s): 尾崎由基男、和田英夫
  • Total Pages: 1-221
• [Remarks]
  • URL: http://www.nedic.mic-u.ac.jp/th-center/