Developing early diagnostic markers of neuropathy with collagen disease and establishment of the clinical examination scheduling process

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590632
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kumamoto University
• Principal Investigator: OBAYASHI Konen 熊本大学, 医学部附属病院, 講師 (90361899)
• Co-Investigator(Kenkyū-buntansha): ANDO Yukio 熊本大学, 大学院・生命科学研究部, 教授 (20253742)
• Project Period (FY): 2009 – 2011
• Keywords: 膠原病 / シェーグレン症候群 / 後根神経節炎 / 自律神経ニューロパチー

Research Abstract

In this study, we tried to develop early diagnostic markers of neuropathy with collagen disease and establish the clinical examination scheduling process. Our results suggest that quantitative sensory testing(QST), laser-Doppler flowmetry, and skin biopsy are the most useful methods to diagnose the neuropathy with collagen disease. Moreover, we could pick up many proteins and peptides which have the potential to become early diagnostic markers of the disease.

Research Products

• [Journal Article] Focus on autonomic dysfunction in familial amyloidotic polyneuropathy(FAP) (2012)
  • Author(s): Obayashi K, Ando Y
  • Journal Title: Amyloid Volume: 19(Suppl 1) Pages: 28-29
  • Peer Reviewed
• [Journal Article] 新しい自律神経機能検査法の構築と臨床応用 (2012)
  • Author(s): 大林光念
  • Journal Title: 臨床病理 Volume: 60 Pages: 435-442
• [Journal Article] Comparison of quantitative sensory testing and heart rate variability in Swedish Val30Met ATTR (2011)
  • Author(s): Heldestad V, Wiklund U, Hornsten R, Obayashi K, Suhr OB, Nordh E
  • Journal Title: Amyloid Volume: 18 Pages: 183-190
  • Peer Reviewed
• [Journal Article] Amyloid neuropathy in a younger domino liver-transplanted recipient (2011)
  • Author(s): Obayashi K, Yamashita T, Tasaki M, Ueda M, Shono M, Jono H, Ohshima T, Ohya Y, Asonuma K, Inomata Y, Ando Y
  • Journal Title: Muscle Nerve Volume: 43 Pages: 449-450
  • Peer Reviewed
• [Journal Article] Blood pressure overshoot after tilt reversal in patients with familial amyloidotic polyneuropathy (2011)
  • Author(s): Obayashi K, Hornsten R, Wiklund U, Karlsson M, Okamoto S, Ando Y, Suhr OB
  • Journal Title: Hypertens Res Volume: 34 Pages: 133-138
  • Peer Reviewed
• [Journal Article] Haemodynamic responses after tilt reversal in FAP (2011)
  • Author(s): Obayashi K, Hornsten R, Wiklund U, Karlsson M, Okamoto S, Ando Y, Suhr OB
  • Journal Title: Amyloid Volume: 18(Suppl1) Pages: 166-168
  • Peer Reviewed
• [Journal Article] Amyloid turnover after liver transplantation in FAP (2011)
  • Author(s): Obayashi K, Ueda M, Misumi Y, Yamashita T, Jono H, Tasaki M, Shono M, Yazaki M, Kametani F, Ohya Y, Asonuma K, Inomata Y, Ikeda SI, Ando Y
  • Journal Title: Amyloid Volume: 18(Suppl1) Pages: 187-189
  • Peer Reviewed
• [Journal Article] Continuous development of arrhythmia is observed in swedish transplant patients with familial amyloidotic polyneuropathy(amyloidogenic transthyretin Val30Met variant) (2011)
  • Author(s): Okamoto S, Hornsten R, Obayashi K, Wijayatunga P, Suhr OB
  • Journal Title: Liver Transplant Volume: 17 Pages: 122-128
  • Peer Reviewed
• [Journal Article] 各種ニューロパチーの早期診断と重症度ならびに治療効果の判定 (2011)
  • Author(s): 大林光念、安東由喜雄
  • Journal Title: 自律神経 Volume: 48 Pages: 328-330
  • Peer Reviewed
• [Journal Article] 内科医が知っておくべき検査の最新情報:臨床検査の進歩注目される新しい検査を中心に神経内科疾患 (2011)
  • Author(s): 安東由喜雄、大林光念、植田光晴
  • Journal Title: 日本内科学会雑誌 Volume: 100 Pages: 3276-3283
• [Journal Article] Investigation of AGE, their receptor and NF-kappaB activation and apoptosis in patients with ATTR and Gelsolin amyloidosis (2010)
  • Author(s): Anan I, Kiuru-Enari S, Obayashi K, Ranlov PJ, Ando Y
  • Journal Title: Histol Histopathol Volume: 25 Pages: 291-699
  • Peer Reviewed
• [Journal Article] Gastric myoelectrical activities in elderly severe tetanus : Useful marker to increase volume and calorie of nasogastric tube feeding (2010)
  • Author(s): Obayashi K, Ueda M, Yamashita T, Misumi Y, Hirahara T, Tasaki M, Ohshima T, Uchino M, Ando Y
  • Journal Title: e-SPEN Volume: 5 Pages: e261-e264
  • Peer Reviewed
• [Journal Article] A possible role for miRNA silencing in disease phenotype variation in Swedish transthyretin V30M carriers (2010)
  • Author(s): Olsson M, Norgen N, Obayashi K, Plante-Bordeneuve V, Suhr OB, Cederquist K, Jonasson J
  • Journal Title: BMC Med Genet Volume: 11 Pages: 130
  • Peer Reviewed
• [Journal Article] 近赤外分光法補遺版:光トポグラフィに関する最新知見 (2010)
  • Author(s): 大林光念、安東由喜雄
  • Journal Title: 自律神経 Volume: 47 Pages: 30-31
  • Peer Reviewed
• [Journal Article] 糖尿病合併症診断のための生理機能検査.各論2.自律神経機能検査 (2010)
  • Author(s): 大林光念、安東由喜雄
  • Journal Title: Medical Technology Volume: 38 Pages: 346-351
• [Journal Article] Chain reaction of amyloid fibril formation with induction of basement membrane in familial amyloidotic polyneuropathy (2009)
  • Author(s): Misumi Y, Ando Y, Ueda M, Obayashi K, Jono H, Su Y, Yamashita T, Uchino M
  • Journal Title: J Pathol Volume: 219 Pages: 481-490
  • Peer Reviewed
• [Journal Article] Liver transplantation for familial amyloidotic polyneuropathy : impact on Swedish patients' survival (2009)
  • Author(s): Okamoto S, Wixner J, Obayashi K, Ando Y, Ericzon BG, Friman S, Uchino M, Suhr OB
  • Journal Title: Liver Transpl Volume: 15 Pages: 1229-1235
  • Peer Reviewed
• [Journal Article] FAPの神経症候と肝移植の効果 (2009)
  • Author(s): 大林光念、安東由喜雄
  • Journal Title: 神経内科 Volume: 70 Pages: 348-353
• [Presentation] Iatrogenic amyloid neuropathy in a younger domino liver-transplanted recipient (2011)
  • Author(s): Obayashi K, Yamashita T, Ueda M, Misumi Y, Ohshima T, Tasaki Masayoshi, Ohya Y, Asonuma K, Inomata Y, Ando Y
  • Organizer: VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
  • Place of Presentation: Kumamoto, Japan
  • Year and Date: 20111120-22
• [Presentation] Autonomic dysfunction in familial amyloidotic polyneuropathy(FAP) (2011)
  • Author(s): Obayashi K, Ando Y
  • Organizer: VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
  • Place of Presentation: Kumamoto, Japan
  • Year and Date: 2011-11-20
• [Presentation] 新しい自律神経機能検査法の構築と臨床応用 (2011)
  • Author(s): 大林光念
  • Organizer: 第58回日本臨床検査医学会学術集会
  • Place of Presentation: 岡山市
  • Year and Date: 2011-11-18
• [Presentation] Aδ特異的痛覚閾値検査と皮膚血流検査,発汗機能検査を組み合わせた小径線維ニューロパチーの早期診断法 (2011)
  • Author(s): 大林光念、山下太郎、植田光晴、三隅洋平、大嶋俊範、安東由喜雄
  • Organizer: 第64回日本自律神経学会総会
  • Place of Presentation: 秋田市
  • Year and Date: 2011-10-25
• [Presentation] 家族性アミロイドポリニューロパチー患者における異型トランスサイレチンに対する自己抗体の探索 (2011)
  • Author(s): 大林光念、植田光晴、城野博史、田崎雅義、安東由喜雄
  • Organizer: 第51回日本臨床化学会年次学術集会
  • Place of Presentation: 札幌市
  • Year and Date: 2011-08-26
• [Presentation] 食後高血糖(IGT)患者における末梢神経障害、内臓神経障害の出現頻度と治療可逆性 (2011)
  • Author(s): 大林光念、植田光晴、大嶋俊範、山下太郎、三隅洋平、安東由喜雄
  • Organizer: 第52回日本神経学会学術集会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-05-18
• [Presentation] 若年のドミノ肝移植レシピエントに生じたアミロイドニューロパチー (2010)
  • Author(s): 大林光念、山下太郎、植田光晴、大嶋俊範、安東由喜雄
  • Organizer: 第63回日本自律神経学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 20101022-23
• [Presentation] 私はこのように自律神経機能検査を用いている:各種ニューロパチーの早期診断と重症度ならびに治療効果の判定 (2010)
  • Author(s): 大林光念
  • Organizer: 第63回日本自律神経学会(教育セミナー)
  • Place of Presentation: 横浜市
  • Year and Date: 20101022-23
• [Presentation] IGT患者における末梢神経障害ならびに内臓神経障害の出現頻度と治療可逆性 (2010)
  • Author(s): 大林光念、今村華奈子、植田光晴、庄野信、城野博史、池田勝義、安東由喜
  • Organizer: 第57回日本臨床検査医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20100909-10
• [Presentation] FAP患者における起立後再臥床時の血圧オーバーシュート現象 (2010)
  • Author(s): 大林光念、Rolf Hornsten、Urban Wiklund、Marcus Karlsson、Ole B Suhr、植田光晴、三隅洋平、山下太郎、安東由喜雄
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
  • Year and Date: 20100520-22
• [Presentation] Hemodynamic responses after tilt reversal in FAP (2010)
  • Author(s): Obayashi K, Hornsten R, Wiklund U, Karlsson M, Okamoto S, Ando Y, Suhr OB
  • Organizer: XII International Symposium on Amyloidosis
  • Place of Presentation: Rome, Italy
  • Year and Date: 20100418-21
• [Presentation] Liver transplantation promoted amyloid turnover in FAP (2010)
  • Author(s): Obayashi K, Ueda M, Misumi Y, Yamashita T, Jono H, Tasaki M, Shono M, Yazaki M, Kametani F, Ohya Y, Asonuma K, Inomata Y, Ikeda S, Ando Y
  • Organizer: XII International Symposium on Amyloidosis
  • Place of Presentation: Rome, Italy
  • Year and Date: 20100418-21
• [Presentation] 家族性アミロイドポリニューロパチー(FAP)患者における局所皮膚加温による皮膚血流量の変化と四肢末梢に生じる自覚的冷感の出現メカニズムについて (2009)
  • Author(s): 大林光念、植田光晴、三隅洋平、山下太郎、安東由喜雄
  • Organizer: 第62回日本自律神経学会総会
  • Place of Presentation: 和歌山市
  • Year and Date: 20091105-06
• [Presentation] 心拍変動検査、皮膚温度感覚閾値検査から見たFAPの発症年齢とニューロパチーの進行パターンとの関係 (2009)
  • Author(s): 大林光念、田崎雅義、植田光晴、堀端洋子、城野博史、安東由喜雄
  • Organizer: 第56回日本臨床検査医学会学術集会
  • Place of Presentation: 札幌市
  • Year and Date: 20090826-30
• [Presentation] IGTニューロパチーの診断と治療可逆性 (2009)
  • Author(s): 大林光念、植田光晴、三隅洋平、城野博史、安東由喜雄
  • Organizer: 第27回日本神経治療学会総会
  • Place of Presentation: 熊本市
  • Year and Date: 20090611-12
• [Presentation] アミロイド蛋白への治療アプローチ-家族性アミロイドポリニューロパチーをモデルとして- (2009)
  • Author(s): 大林光念、安東由喜雄
  • Organizer: 第60回日本電気泳動学会(シンポジウム)
  • Place of Presentation: 松本市
  • Year and Date: 2009-09-13
• [Presentation] 心臓自律神経機能と四肢末梢の小径有髄、無髄線維の機能から見た、FAPの発症年齢とニューロパチーの進行パターンとの関係 (2009)
  • Author(s): 大林光念、植田光晴、Victoria Heldestad、Urban Wiklund、Rolf Hornstedt、Ole Suhr、Erik Nordh、安東由喜雄
  • Organizer: 第50回日本神経学会総会
  • Place of Presentation: 仙台市
  • Year and Date: 2009-05-20
• [Remarks]
  • URL: http://www2.kuh.kumamoto-u.ac.jp/amyloidunit/