2011 Fiscal Year Final Research Report
Multi-marker serum test for early colorectal cancer.
| Project/Area Number |
21590636
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUI Takeshi 京都大学, 物質-細胞統合システム拠点, 助教 (10452442)
OCHIAI Toshiya 京都府立医科大学, 医学研究科, 准教授 (30311913)
OTSUJI Eigo 京都府立医科大学, 医学研究科, 教授 (20244600)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 腫瘍検査学 |
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| Research Abstract |
We established an experimental enzyme-linked immunosorbent assay(ELISA) to detect Dermokine the serum of colorectal cancer patients. DK test improved the positive detection rate for early-stage tumors. The sensitivity was 60.7% to detect T1 colorectal cancer using multi-marker test(DK and CEA/CA19-9/p53, n=130). DK test was useful to detect pancreatic cancer including IPMN and invasive ductal carcinoma.
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[Journal Article] Dermokine as a novel biomarker for early-stage colorectal cancer2010
Author(s)
Tagi T, Matsui T, Kikuchi S, Hoshi S, Ochiai T, Kokuba Y, Kinoshita-Ida Y, Kisumi-Hayashi F, Morimoto K, Imai T, Imoto I, Inazawa J, Otsuji E.
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Journal Title
J Gastroenterol.
Volume: 45(12)
Pages: 1201-11
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