2011 Fiscal Year Final Research Report
Studies on the early cancer detection with urinary diacetylspermine and its application
| Project/Area Number |
21590639
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | 財団法人東京都医学総合研究所 (2011)
Tokyo Metropolitan Organization for Medical Research (2009-2010) |
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Principal Investigator |
KAWAKITA Masao 財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 (00012740)
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| Co-Investigator(Renkei-kenkyūsha) |
HIRAMATSU Kyouko 財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主任研究員 (80181189)
TAKAHASHI Kei-ichi 財団法人東京都医学総合研究所, ゲノム医科学研究分野,がん・感染症センター東京都立駒込病院外科, 客員研究員,部長 (60443115)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 尿検査 / 腫瘍マーカー / ポリアミン / ジアセチルスペルミン / 大腸がん / イムノクロマトグラフィー / 早期がん |
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| Research Abstract |
N^1, N^<12>-diacetylspermine(DiAcSpm) in urine is frequently increased in cancer patients at earlier stages of the disease and hence is considered as promising tumor marker. In the present study we first analyzed the urinary DiAcSpm level of healthy persons in detail, and established cut-off values to distinguish between normal and abnormal levels of DiAcSpm excretion. We then developed an immunochromatographic device for simple and rapid DiAcSpm determination. The spreading of this simple determination procedure may help in increasing the opportunity of early detection of cancer patients. Our further analysis revealed that DiAcSpm is increased in cancer tissues from very early stages of cancer development. This finding provides us with a new method for early cancer detection on one hand, and a useful clue to answer the question of why DiAcSpm is increased in the urine from early cancer patients.
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[Journal Article] 癌組織中のN^1, N^<12>-ジアセチルスペルミン2012
Author(s)
高橋慶一,平松恭子,桑田剛,八杉利治,岩崎善毅,堀尾裕俊,堀口慎一郎,小泉浩一,岩崎香里,森谷俊介,川喜田正夫
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Journal Title
日本分子腫瘍マーカー研究会誌
Volume: 27
Pages: 37-38
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[Journal Article] 大腸癌組織中のN^1, N^<12>-ジアセチルスペルミン2011
Author(s)
桑田剛,平松恭子,小泉浩一,高橋慶一,鮫島啓二郎,三浦正子,森谷俊介,斎藤文江,酒井麻美,川喜田正夫
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Journal Title
日本分子腫瘍マーカー研究会誌
Volume: 26
Pages: 70-71
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[Journal Article] 非小細胞肺がんにおける尿中ジアセチルスペルミン測定の意義2010
Author(s)
坂口幸治,平松恭子,山本学,原田国彦,堀尾裕俊,森谷俊介,盛山優子,三浦正子,斎藤文江,高橋慶一,川喜田正夫
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Journal Title
日本分子腫瘍マーカー研究会誌
Volume: 25
Pages: 55-56
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[Journal Article] 膵がんにおける尿中ジアセチルスペルミン陽性率の検討2009
Author(s)
江川直人,平松恭子,来間佐和子,神澤輝実,森谷俊介,盛山優子,斎藤文江,高橋慶一,倉田昌直,本田五郎,鶴田耕二,川喜田正夫
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Journal Title
日本分子腫瘍マーカー研究会誌
Volume: 24
Pages: 33-34
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