2011 Fiscal Year Final Research Report
Protective effects of endogenous digitalislike factor on the injury of kidney by aldosterone
| Project/Area Number |
21590643
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIKA Masamichi 関西医科大学, 医学部, 助教 (70434834)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Hakuo 関西医科大学, 医学部, 教授 (80094431)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 内因性ジギタリス / アルドステロン / 視床下部 / 腎障害 / 臨床検査 |
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| Research Abstract |
This research is a part of patho-physiological study of endogenous digitalislike factor(EDLF) To realize aldosterone injury on the kidney function, new information of EDLF production in peripheral organ such as adrenal and heart were obtained. And, as a central modulation system of EDLF bio-activity, a production of marinobufotoxin(MBT) in PC12 cell derived from nerve system cell-line was demonstrated as the first report in the world. Moreover, participation of N-1 cell derived from hypothalamus cell line to the ouabain production was demonstrate. This is also the first report.
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