2012 Fiscal Year Final Research Report
Epidemiologic and experimental study to clarify involvement of heavy metals in Parkinson's disease
| Project/Area Number |
21590657
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANDA Hideyuki 福島県立医科大学, 福島県立医科大学, 講師 (80294370)
HAYAKAWA Takehito 福島県立医科大学, 医学部, 准教授 (50362918)
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| Research Collaborator |
TAN Xiaodong 武漢大学, 公共衛生学院, 教授
ZHANG Junjiang 武漢大学, 医学院, 教授
LUO Yunwen 中国湖北襄樊市第一人民医院, 教授
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| Project Period (FY) |
2009 – 2012
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| Keywords | 予防医学 |
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| Research Abstract |
From the results of the case-control study in China comparing concentrations of metals and vitamins in blood and urine, excessive intake of iron and copper, accumulation of manganese, vitamin E/copper imbalance in intake, and vitamin B12 decrease by zinc deficiency in the body might be involved in the etiology of Parkinson's disease.Our experimental study using Mouse CD1 brain striatum neuronal cells suggests the possibility that manganese causes increased nicotinamide N-methyltransferase activity, thereby increasing 1-methylnicotinamide levels in the brain and bringing about neuron death.
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