2011 Fiscal Year Final Research Report
Genetic epidemiological study on metabolic syndrome and its application to personalized health promotion
| Project/Area Number |
21590658
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MURE Kanae 和歌山県立医科大学, 医学部, 講師 (90268491)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肥満 / メタボリックシンドローム / アディポネクチン / コーヒー / 内臓脂肪 / 生活習慣 / 遺伝子多型 / アルデヒド脱水素酵素 / アルコール |
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| Research Abstract |
The association of coffee consumption and MetS-related biomarkers including visceral and subcutaneous fat area(VFA and SFA), total, low-, medium-and high-molecularweight serum adiponectin(T-, LMW-, MMW-and HMW-Ad)levels were analyzed among a total of 364 Japanese male workers(36-61 y old)adjusting for age, alcohol drinking, smoking, walking status and BMI. Both light(1-3 cups/day)and moderate (〓4cups/day)coffee consumption showed significant inverse associations with VFA and VFAISFA ratio(P<0.0001). Moderate coffee consumption showed a favorable tendency toward these associations with T-Ad(P=0.06)and HMW-Ad(P=0.07)levels.
The relationship between coffee consumption and the prevalence of metabolic syndrome was investigated in Japanese civil servants. The study participants were 3284 employees(2335 men and 948 women)aged 20 to 65 years. Metabolic syndrome was diagnosed in 3740f the 2335 men(16.0%)and 320f the 948 women(3.4%). In multiple logistic regression analyses, the odds ratios(ORs)among men fbr the presence of metabolic syndrome were 0.61(0.39-0.95), among moderate(〓4 cups of coffee per day)coffee drinkers as compared with non-coffee drinkers. Among all components of metabolic syndrome, high blood pressure and high triglyceride level were inversely associated with moderate coffee consumption in men, after adjusting for age, body mass index, smoking status, drinking status, and exercise. However, in women, moderate coffee consumption was not significantly associated with the prevalence of metabolic syndrome or its components.
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Research Products
(23 results)
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[Journal Article] Development of gastric cancer in nonatrophic stomach with highly active inflammation identified by serum levels of pepsinogen and Helicobacter pylori antibody together with endoscopic rugal hyperplastic gastritis2012
Author(s)
Watanabe M, Kato J, Inoue I, Yoshimura N, Yoshida T, Mukoubayashi C, Deguchi H, Enomoto S, Ueda K, Maekita T, Iguchi M, Tamai H, Utsunomiya H, Yamamichi N, Fujishiro M, Iwane M, Tekeshita T, Mohara O, Ushijima T, Ichinose M
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Journal Title
Int J Cancer
Volume: 131巻
Pages: 2632-2642
DOI
Peer Reviewed
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[Journal Article] Skin sensitization study by a new qualitative structure-toxicity relationships (QSTR) approach : K-step Yard sampling (KY) methods2012
Author(s)
Sato K, Umemura T, Tamura T, Kusaka Y, Aoyama K, Ueda A, Harada K, Minamoto K, Otsuki T, Yamashita K, Haitsuka M, Takeshita T, Shibata E, Dobashi K, Kameo S, Miyagawa M, Kaniwa M, Yoshida T, Fukushima T, Yuta K
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Journal Title
J Oral Tissue Engin
Volume: 9巻
Pages: 167-173
Peer Reviewed
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[Journal Article] Elevated risk of colorectal adenoma with Helicobacter pylori-related chronic gastritis2011
Author(s)
Inoue I, Mukoubayashi C, Yoshimura N, Niwa T, Deguchi H, Watanabe M, Enomoto S, Maekita T, Ueda K, Iguchi M, Yanaoka K, Tamai H, Arii K, Oka M, Fujishiro M, Takeshita T, Iwane M, Mohara O, Ichinose M
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Journal Title
a population-based case-control study
Volume: 129巻
Pages: 2704-2711
DOI
Peer Reviewed
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[Journal Article] A respiratory sensitization study by a new quantitative structure-activity relationships (QSAR)2010
Author(s)
Sato K, Umemura T, Tamura T, Kusaka Y, Ido T, Aoyama K, Ueda A, Harada K, Minamoto K, Otsuki T, Yamashita K, Takeshita T, Shibata E, Dobashi K, Kameo S, Miyagawa M, Kaniwa M, Yoshida T, Fukushima T, Yuta K
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Journal Title
AATEX
Volume: 15巻
Pages: 124-130
Peer Reviewed
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[Journal Article] Upregulation of fractalkine and its receptor, CX3CR1, is associated with coronary plaque rupture in patients with unstable angina pectoris2010
Author(s)
Ikejima H, Imanishi T, Tsujioka H, Kashiwagi M, Kuroi A, Tanimoto T, Kitabata H, Ishibashi K, Komukai K, Takeshita T, Akasaka T
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Journal Title
Circ J
Volume: 74巻
Pages: 337-345
URL
Peer Reviewed
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[Journal Article] Preventive effects of etodolac, a selective cyclooxygenase-2 inhibitor, on cancer development in extensive metaplastic gastritis, a Helicobacter pylori-negative precancerous lesion2010
Author(s)
Yanaoka K, Oka M, Yoshimura N, Deguchi H, Mukoubayashi C, Enomoto S, Maekita T, Inoue I, Ueda K, Utsunomiya H, Iguchi M, Tamai H, Fujishiro M, Nakamura Y, Tsukamoto T, Inada K, Takeshita T, Ichinose M
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Journal Title
Int J Cancer
Volume: 126巻
Pages: 1467-1473
DOI
Peer Reviewed
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[Presentation] 職域男性における飲酒量と血清総アディポネクチン値との関連性の解析2010
Author(s)
前田真也,牟礼佳苗,竹下達也,渡辺実香,向林知津,麦谷耕一,渡辺豊,岩根幹能,木下藤寿,湯川修也,茂原治
Organizer
第83回日本産業衛生学会
Place of Presentation
福井市
Year and Date
20100500
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