• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

Quantitative risk assessment for death and incident stroke attributable to atrial fibrillation in hemodilaysis patients

Research Project

  • PDF
Project/Area Number 21590660
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionIwate Medical University

Principal Investigator

OSAWA Masaki  岩手医科大学, 医学部, 講師 (60295970)

Co-Investigator(Renkei-kenkyūsha) FUJIOKA Tomoaki   (80173409)
SAKATA Kiyomi   (50225794)
NAKAMURA Motoyuki   (40172449)
ITAI Kazuyoshi   (10048572)
KATO Karen   (20405749)
TANNO Kozo   (20327026)
OKAMURA Tomonori   (00324567)
Project Period (FY) 2009 – 2011
Keywords循環器高血圧 / 社会医学 / 脳神経疾患 / 内科 / 臨床
Research Abstract

A total of 1510 adult hemodialysis patients who lived in northern part of Iwate prefecture and 26, 469 community-dwelling people who lived in the same area were enrolled. Prevalences of atrial fibrillation(AF) were 3.8% in hemodialysis patients and 1.5% in community dwelling people, respectively. Standardized prevalence ratios(95% confidence intervals) of AF in hemodialysis patients compared to those in community-dwelling people were 2.59(1.91-3.26) in total subjects, 1.80(1.29-2.30) in male subjects and 2.15(0.66-3.63) in female subjects, respectively.
Prospective cohort studies were carried out. There were 3909 person-years(mean 3.9 years) in hemodilaysis patients cohort study(n=1, 009) and 147, 513 person-years(mean 5.6 years) in community-dwelling people cohort study(n=26, 469). Crude mortality rates of all-cause, cardiovascular and infectious disease-related and crude incidence rates of acute myocardioal infarction(AMI) and stroke(AF vs. non-AF) were 279 vs. 88.7、96.5 vs. 43.2、96.5 … More vs. 22.9、22.0 vs. 11.3、55.2 vs. 47.3, respectively, in hemodilaysis patients and those were 25.9 vs. 6.84, 12.2 vs. 1.46, 4.70 vs. 0.8, 2.37 vs. 0.59, 28.7 vs. 4.81, respectively, in community-dwelling people.
Sex-and age-adjusted mortality(incidence) rate ratios attributable to AF were estimated by Poisson regression analysis after adjusting for persons aged 60-year old and adjusting for male to female ratio being 1.0.Adjusted mortality rate ratios(95% confidence intervals) of all-cause were 1.76(1.34-2.31) in community-dwelling people, 1.70(1.13-2.65) in hemodialysis patients, respectively. Rate ratios of cardiovascular death were 3.91(2.58-5.91) in community-dwelling people, 1.27(0.64-2.50) in hemodialysis patients, respectively. Rate ratios of infectious disease-related death were 1.89(0.99-3.6) in community-dwelling people, 2.22(1.09-4.50) in hemodialysis patients. Rate ratio of incident stroke was 3.41(2.59-4.51) in community-dwelling people. Increased risks for incident AMI and incident stroke were not observed in hemodialysis patients.
Hemodilayis patients have a two-fold high prevalence of AF compared to that in general population. Persons with AF had a 1.7-fold high risk for all-cause death compared to that in persons without AF both in hemodilysis patients and general population. Significantly elevated risks for cardiovascular death and incident stroke attributable to AF were observed in general population, whilst they were not observed in hemodialysis patients. Less

  • Research Products

    (25 results)

All 2012 2011 2010 2009 Other

All Journal Article (16 results) Presentation (9 results)

  • [Journal Article] Seropositivity for Anti-HCV Core antigen is Independently Associated With Increased All-Cause, Cardiovascular, and Liver Disease-Related Mortality in Hemodialysis Patients2011

    • Author(s)
      Ohsawa M
    • Journal Title

      J Epidemiol

      Volume: 21(6) Pages: 491-9

  • [Journal Article] Serum low-density lipoprotein to high-density lipoprotein ratio as a predictor of future acute myocardial infarction among men in a 2.7-year cohort study of a Japanese northern rural population2011

    • Author(s)
      Yokokawa H, Yasumura S, Tanno K, Ohsawa M, Onoda T, Itai K
    • Journal Title

      J Atheroscler Thromb

      Volume: 18(2) Pages: 89-98

  • [Journal Article] Serum C-reactive protein levels and death and cardiovascular events in mild to moderate chronic kidney disease2011

    • Author(s)
      Koeda Y, Nakamura M, Tanaka F, Onoda T, Itai K, Tanno K, Ohsawa M
    • Journal Title

      Int Heart J

      Volume: 52(3) Pages: 180-4

  • [Journal Article] Serum selenium levels are inversely associated with death risk among hemodialysis patients2011

    • Author(s)
      Fujishima Y, Ohsawa M, Itai K, Kato K, Tanno K, Turin TC
    • Journal Title

      Nephrol Dial Transplant

      Volume: 26(10) Pages: 3331-8

  • [Journal Article] Sex-specific threshold levels of plasma B-type natriuretic Peptide for prediction of cardiovascular event risk in a Japanese population initially free of cardiovascular disease2011

    • Author(s)
      Nakamura M, Itai K, Ohsawa M, Tanno K, Sakata K
    • Journal Title

      Am J Cardiol

      Volume: 108(11) Pages: 1564-9

  • [Journal Article] Standardized prevalence ratios for chronic hepatitis C virus infection among adult Japanese hemodialysis patients2010

    • Author(s)
      Ohsawa M
    • Journal Title

      J Epidemiol

      Volume: 20(1) Pages: 30-9

  • [Journal Article] Serum ionic fluoride concentrations are related to renal function and menopause status but not to age in a Japanese general population2010

    • Author(s)
      Itai K, Onoda T, Nohara M, Ohsawa M, Tanno K, Sato T
    • Journal Title

      Clin Chim Acta

      Volume: 411 Pages: 263-266

  • [Journal Article] Comparison of low-density lipoprotein cholesterol concentrations measured by a direct homogeneous assay and by the Friedewald formula in a large community population2010

    • Author(s)
      Tanno K, Okamura T, Ohsawa M, Onoda T, Itai K, Sakata K
    • Journal Title

      Clin Chim Acta

      Volume: 411(21-22) Pages: 1774-80

  • [Journal Article] Plasma B-type natriuretic peptide level and cardiovascular events in chronic kidney disease in a community-based population2010

    • Author(s)
      Sakuma M, Nakamura M, Tanaka F, Onoda T, Itai K, Tanno K, Ohsawa M
    • Journal Title

      A. Circ J

      Volume: 74(4) Pages: 792-7

  • [Journal Article] Iwate-KENCO Study Group. Prehypertension subtype with elevated C-reactive protein : risk of ischemic stroke in a general Japanese population2010

    • Author(s)
      Tanaka F, Makita S, Onoda T, Tanno K, Ohsawa M, Itai K.
    • Journal Title

      Am J Hypertens

      Volume: 23(10) Pages: 1108-13

  • [Journal Article] Gender-specific risk stratification with plasma B-type natriuretic peptide for future onset of congestive heart failure and mortality in the Japanese general population2010

    • Author(s)
      Nakamura M, Tanaka F, Onoda T, Takahashi T, Sakuma M, Kawamura K, Tanno K, Ohsawa M
    • Journal Title

      Int J Cardiol

      Volume: 143(2) Pages: 124-9

  • [Journal Article] Cardiovascular risk factors in the Japanese northeastern rural population2009

    • Author(s)
      Ohsawa M
    • Journal Title

      Int J Cardiol

      Volume: 37 Pages: 226-235

  • [Journal Article] Serum C-reactive protein levels can be used to predict future ischemic stroke and mortality in Japanese men from the general population2009

    • Author(s)
      Makita S, Nakamura M, Satoh K, Tanaka F, Onoda T, Kawamura K, Ohsawa M
    • Journal Title

      Atherosclerosis

      Volume: 204 Pages: 234-8

  • [Journal Article] Associations of ikigai as a positive psychological factor with all-cause mortality and cause-specific mortality among middle-aged and elderly Japanese people : findings from the Japan Collaborative Cohort Study2009

    • Author(s)
      Tanno K, Sakata K, Ohsawa M, Onoda T, Itai K, Yaegashi A
    • Journal Title

      J Psychosom Res

      Volume: 67(1) Pages: 67-75

  • [Journal Article] Predictive value of plasma B-type natriuretic peptide for ischemic stroke : a community-based longitudinal study2009

    • Author(s)
      Takahashi T, Nakamura M, Onoda T, Ohsawa M, Tanno K, Itai K
    • Journal Title

      Atherosclerosis

      Volume: 207 Pages: 298-303

  • [Journal Article] Serum Selenium Levels in Hemodialysis Patients Are Significantly Lower than Those in Healthy

    • Author(s)
      Fujishima Y, Ohsawa M, Itai K, Kato K, Tanno K, Turin TC
  • [Presentation] Elevated serum arsenic levels are associated with high risks for peripheral artery disease-related death and incident myocardial infarction among Japanese hemodialysis patients2012

    • Author(s)
      Ohsawa M, et al.
    • Organizer
      WCN Vancouver
    • Year and Date
      20120408-12
  • [Presentation] Insufficient sleeping time was associated with a high risk for sudden cardiac death and excessive sleeping time was associated with a high risk for cerebrovascular death among hemodialysis patients2012

    • Author(s)
      Ohsawa M, et al.
    • Organizer
      52th AHA CVD EPIC Conference
    • Place of Presentation
      San Diego, CA
    • Year and Date
      2012-03-13
  • [Presentation] The combined classification of CKD-EPI equation and UACR predicts more accurate risks for death, incident AMI and stroke2011

    • Author(s)
      Ohsawa M, et al.
    • Organizer
      51th AHA CVD EPIC
    • Place of Presentation
      Atlanta, GA
    • Year and Date
      20110322-25
  • [Presentation] Risk assessment of CKD-EPI equation compared with that based on MDRD study equation in the Japanese general population2011

    • Author(s)
      Ohsawa M, et al.
    • Organizer
      2011 Annual Meeting of ASN Philadelphia
    • Year and Date
      2011-11-10
  • [Presentation] Risk assessment of CKD-EPI equation compared with that based on MDRD study equation in the Japanese general population2011

    • Author(s)
      Ohsawa M, et al.
    • Organizer
      2011 ASN Philadelphia
    • Year and Date
      2011-11-10
  • [Presentation] Chronic HCV infection independently increased mortality risks for cardiovascular and liver disease-related death in hemodialysis patients, while past HCV infection did not2010

    • Author(s)
      Ohsawa, M, et al.
    • Organizer
      2010 ASN Denver
    • Year and Date
      20101116-21
  • [Presentation] Japanese Hemodialysis Patients Have 7 to 20-fold Higher Mortality Risks And 6 to 8-fold Higher Incidence Rates Of Stroke Than Those In Normal Controls2009

    • Author(s)
      Ohsawa M, et al.
    • Organizer
      The 49th AHA CVD EPIC Conference
    • Place of Presentation
      Florida
    • Year and Date
      20090310-14
  • [Presentation] Relative risks for total mortality, incident myocardial infarction and incident stroke among2009

    • Author(s)
      Ohsawa M, et al.
    • Organizer
      Japanese hemodialysis patients ESC Congress 2009
    • Place of Presentation
      Barcelona
    • Year and Date
      2009-09-02
  • [Presentation] Elevated serum levels of copper independently contribute to an increased mortality in adult hemodialysis patients

    • Author(s)
      Ohsawa M, et al.
    • Organizer
      WCN
    • Place of Presentation
      Milan, Italy
    • Year and Date
      00000522-29

URL: 

Published: 2013-07-31  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi