2011 Fiscal Year Final Research Report
Effects of mild hypoxia on the restoration in cerebral blood flow during temporal decreases in blood pressure and dynamic cerebral autoregulation.
| Project/Area Number |
21590667
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AOKI Ken 日本大学, 医学部, 助教 (60332938)
OGAWA Yojiro 日本大学, 医学部, 助教 (60434073)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 環境 / 生理学 / 脳血流自動調節 / 低酸素 / 失神 |
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| Research Abstract |
We conducted this study estimating the restoration rate in cerebral blood flow during temporal decreases in blood pressure, to test our hypothesis that dynamic cerebral autoregulation is impaired during acute exposure to mild hypoxia. The percentage restoration in CBF velocity by thigh cuff deflation decreased significantly during hypoxia Moreover, transfer function coherence and gain in the very-low-frequency range increased significantly. These results provide together a consistent finding that mild hypoxia impairs dynamic cerebral autoregulation, suggesting high risk of syncope at upright posture during mild hypoxia.
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