2011 Fiscal Year Final Research Report
Researches on the target organ and its hazard of engineering nanoparticles by intratracheal instillation
| Project/Area Number |
21590674
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
OYABU Takako 産業医科大学, 産業生態科学研究所, 助教 (20320369)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MYOJO Toshihiko 産業医科大学, 産業生態科学研究所, 教授 (00209959)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | ナノ粒子 / 二酸化チタン / 有害性評価 / 気管内注入試験 / 体内動態 / 排泄速度 |
|---|
| Research Abstract |
Titanium dioxide nanoparticle, rutile crystalline structure, was dispersed in distilled water and average 55 nm size particles were fractionated by ultracentrifugation. 0.2 mg and 0.5mg TiO2 were intratracheally instilled into rat's lung. The amounts of TiO2 in lungs, bloods, livers, kidneys, spleens were determined by ICP-AES subsequently. TiO2 were cleared from lungs and the biological half time of were 3.4 months(0.2mg) and 3.9 months(0.5mg). TiO2 amounts in the other organ and blood were not determined or extremely low. There were no dose-dependent increases of total cells and neutrophils in BALF. The histopathological examination reveals the slight infiltration of inflammatory cells and no fibrosis and hyperplasic changes.
|
