2011 Fiscal Year Final Research Report
Epigentic analyses of hyperactivity by environmental factors
| Project/Area Number |
21590676
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | National Institute for Environmental Studies |
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Principal Investigator |
ISHIDO Masami 独立行政法人国立環境研究所, 環境リスク研究センター, 主任研究員 (60211728)
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| Co-Investigator(Renkei-kenkyūsha) |
MASUO Yoshinori 東邦大学, 理学部, 教授 (60301553)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 環境化学物質 / 脳神経疾患 / エピジェネティックス |
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| Research Abstract |
It has been concerned that environmental chemicals might affect their effects over generation. Therefore, we examined this sense using rotenone models of hyperactive rat. Breeding female hyperactive rats with male ones produced hyperactive rats. Epigenetic modifying reagents altered rat motor activity as seen in rotenone-exposed rats. DNA array analyses indicated the pesticide altered the level of the molecules which are consisted of dopaminergic transduction pathway.
Thus, our study strongly suggests that motor activity could be regulated by epigenetics.
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