Molecular epidemiological study on the evaluation of long-term intake of folic acid, in order to reduce the risk of Down syndrome

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590699
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Nagasaki University
• Principal Investigator: TAKAMURA Noboru 長崎大学, 医歯薬学総合研究科, 准教授 (30295068)
• Co-Investigator(Kenkyū-buntansha): MASUZAKI Hideaki 長崎大学, 医歯薬学総合研究科, 教授 (00173740) ; OHISHI Kazuyo 長崎大学, 医歯薬学総合研究科, 教授 (00194069) ; HAYASHIDA Naomi 長崎大学, 医歯薬学総合研究科, 助教 (00420638)
• Project Period (FY): 2009 – 2011
• Keywords: 母子保健 / ダウン症候群 / 葉酸

Research Abstract

We showed that genetic effects of MTHFR polymorphism on homosysteine metabolism is different in three generations, i. e. new born babies, mothers and elderies.

Research Products

• [Journal Article] Lessons from Chernobyl (2011)
  • Author(s): Takamura N, Yamashita S
  • Journal Title: Fukushima J Med Sci Volume: 57(2) Pages: 81-5
• [Journal Article] Cardiorespiratory fitness and metabolic markers in healthy young adult men (2011)
  • Author(s): Yagura C, Takamura N, Goto Y, Sugihara H, Sota T, Oka S, Shimoda T, Yoshizumi K
  • Journal Title: J Phys Ther Sci Volume: 23(6) Pages: 845-9
• [Journal Article] Factors associated with radiographic osteoarthritis of the knee among community-dwelling Japanese women : the Hizen-Oshima Study (2011)
  • Author(s): Vasilkova O, Mikhort T, Sanec I, Sharshakova T, Hayashida N, Takamura N. Aoyagi K
  • Journal Title: J Orthop Sci Volume: 16(1) Pages: 51-5
• [Journal Article] Longitudinal study to identify factors predicting health-related quality of life in knee osteoarthritis among community-dwelling women in Japan : The Hizen-Oshima Study (2011)
  • Author(s): Norimatsu T, Osaki M, Tomita M, Ye Z, Abe Y, Honda S, Kanagae M, Mizukami S, Takamura N, Kusano Y, Shindo H, Aoyagi K
  • Journal Title: Orthopedics Volume: 34(9) Pages: e535-40
• [Journal Article] Screening for 137Cs Body Burden due to the Chernobyl Accident in Korosten City, Zhitomir, Ukraine : 1996-2008 (2011)
  • Author(s): Hayashida N, Sekitani Y, Kozlovsky A, Rafalsky R, Gutevich O, Daniliuk V, Yamashita S, Takamura N
  • Journal Title: J Rad Res Volume: 52(5) Pages: 629-3
• [Journal Article] Background radiation and individual dosimetry in the costal area of Tamil Nadu, India (2011)
  • Author(s): Matsuda N, Brahmanandhan GM, Yoshida M, Takamura N, Suyama A, Koguchi Y, Juto N, Raj YL, Winsley G, Selvasekarapandian S
  • Journal Title: Radiat Prot Dosimetry Volume: 146(1-3) Pages: 314-7
• [Journal Article] Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults (2011)
  • Author(s): Nakazato M, Maeda T, Takamura N, Wada M, Yamasaki H, Johnston KE, Tamura T
  • Journal Title: Eur J Nut Volume: 50(7) Pages: 581-5
• [Journal Article] Suitability of tartrate-resistant Acid phosphatase type 5b as a screening marker for bone mineral density in community-dwelling elderly individuals (2011)
  • Author(s): Irie S, Hayashida N, Shinkawa T, Taira Y, Sekitani Y, Teraoka S, Hashiguchi K, Yoshida K, Morishita M, Takamura N
  • Journal Title: Tohoku J Exp Med Volume: 224(2) Pages: 105-10
• [Journal Article] Mutational screening of the BRCA1 gene in sporadic breast cancer in the Kazakhstan population (2011)
  • Author(s): Akilzhanova A, Meirmanov S, Zhunussova T, Nakashima M, Takamura N, Akanov Z, Masadykov A, Sandybaev M, Ramankulov E, Yamashita S, Sekine I
  • Journal Title: Breast J Volume: 17(3) Pages: 328-30
• [Journal Article] Prevalence of antithyroid antibodies and thyroid-stimulating hormone concentration in young people (2011)
  • Author(s): Sekitani Y, Hayashida N, Karevskaya IV, Zubareva IA, Kozlovsky A, Yamashita S, Takamura N
  • Journal Title: Clin Chem Lab Med Volume: 49(4) Pages: 747-9
• [Journal Article] Quantitative ultrasound and radiographic absorptiometry are associated with vertebral deformity in Japanese women : the Hizen-Oshima Study (2011)
  • Author(s): Abe Y, Takamura N, Ye Z, Tomita M, Osaki M, Kusano Y, Nakamura T, Aoyagi K, Honda S
  • Journal Title: Osteoporosis Int Volume: 22(4) Pages: 1167-73
• [Journal Article] A proposed method for the evaluation of body fat in Japanese adults that predicts obesity (2011)
  • Author(s): Minematsu K, Takamura N, Goto K, Honda S, Aoyagi K, Moji K, Tsunawake N
  • Journal Title: Nutr Res Volume: 31(2) Pages: 113-21
• [Journal Article] The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan (2011)
  • Author(s): Nakazato M, Takamura N, Kadota K, Yamasaki H, Mukae H, Kusano Y, Nakashima K, Ozono Y, Aoyagi K, Kohno S, Maeda T
  • Journal Title: Acta Med Nagasaki Volume: 55(1) Pages: 47-54
• [Journal Article] Aoyagi K. Factors associated with radiographic osteoarthritis of the knee among community-dwelling Japanese women : the Hizen-Oshima Study (2011)
  • Author(s): Hashikawa K, Osaki M, Ye Z, Tomita M, Abe Y, Honda S, Takamura N, Shindo H
  • Journal Title: J Orthop Sci Volume: 16(1) Pages: 51-5
• [Journal Article] Testosterone is an independent determinant of bone mineral density in men with type 2 diabetes mellitus (2011)
  • Author(s): Vasilkova O, Mikhort T, Sanec I, Sharshakova T, Hayashida N, Takamura N
  • Journal Title: Clin Chem Lab Med Volume: 49(1) Pages: 99-103
• [Journal Article] Current concentration of artificial radionuclides and estimated radiation doses around the Chernobyl Nuclear Power Plant, the Semipalatinsk Nuclear Testing Site, and in Nagasaki (2011)
  • Author(s): Taira Y, Hayashida N, Brahmanandhan GM, Nagayama Y, Yamashita S, Takahashi J, Gutevitc A, Kozlovsky A, Urazalin M, Takamura N
  • Journal Title: J Rad Res Volume: 52(1) Pages: 88-95
• [Journal Article] Urinary iodine concentrations in the high background radiation areas of Kanyakumari district, Tamilnadu, India (2011)
  • Author(s): Brahmanandhan GM, Hayashida N, Taira Y, Malathi J, Khnna D, Selvasekarapandian U, Matsuda N, Takamura N
  • Journal Title: Endocr J Volume: 57(1) Pages: 87-91
• [Journal Article] Subclinical hypothyroidism and the risk of coronary heart disease and mortality (2010)
  • Author(s): Takamura N, Hayashida N, Maeda T
  • Journal Title: JAMA Volume: 304(22) Pages: 2481-2
• [Journal Article] Body mass index positively correlated with forced expiratory volume in 1 second/ forced vital capacity in population with relatively low prevalence of obesity (2010)
  • Author(s): Fukahori S, Matsuse H, Takamura N, Tsuchida T, Kawano T, Fukushima C, Hideaki S, Kohno S
  • Journal Title: Chin Med J Volume: 123(10) Pages: 2792-96
• [Journal Article] Evaluation of 137Cs body burden in inhabitants of Bryansk Oblast, Russian Federation, where a high incidence of thyroid cancer was observed after the accident at the Chernobyl Nuclear Power Plant (2010)
  • Author(s): Sekitani Y, Hayashida N, Karevskaya I, Vasiltsova O, Kozlovsky A, Omiya M, Yamashita S, Takamura N
  • Journal Title: Radiat Prot Dosimetry Volume: 141(1) Pages: 36-42
• [Journal Article] White blood cell count and cardiovascular biomarkers of atherosclerosis (2010)
  • Author(s): Sekitani Y, Hayashida N, Kadota K, Yamasaki H, Abiru N, Nakazato M, Maeda T, Ozono Y, Takamura N
  • Journal Title: Biomarkers Volume: 15(5) Pages: 454-60
• [Journal Article] The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl (2010)
  • Author(s): Takahashi M, Saenko V, Rogounovitch TI, Kawaguchi T, Drozd VM, Takigawa-Imamura H, Akulevich NM, Ratanajaraya C, Mitsutake N, Takamura N, Danilova LI, Lushchik ML, Demidchik YE, Heath S, Yamada R, Lathrop M, Matsuda F, Yamashita S
  • Journal Title: Hum Mol Genet Volume: 19(12) Pages: 2516-23
• [Journal Article] Leptin : high molecular weight adiponectin ratio is independently correlated with carotid intima-media thickness in men, but not in women (2010)
  • Author(s): Takamura N, Hayashida N, Hagane K, Kadota K, Yamasaki H, Abiru N, Ozono Y, Kamihira S, Ishibashi K, Nakazato M, Maeda T
  • Journal Title: Biomarkers Volume: 15(4) Pages: 340-4
• [Journal Article] Percentage body fat assessed by bioelectrical impedance analysis as a new health index for rural areas in the Asia-Pacific region (2009)
  • Author(s): Minematsu K, Kaneko Y, Nakazato M, Maeda T, Christopher NJ, Yoda T, Goto K, Takamura N, Mizota T
  • Journal Title: Acta Med Nagasaki Volume: 54(1) Pages: 39-43
• [Journal Article] Relationship between periodontal status and HbA1c in non-diabetics (2009)
  • Author(s): Hayashida H, Kawasaki K, Yoshimura A, Kitamura M, Furugen R, Nakazato M, Takamura N, Hara Y, Maeda T, Saito T
  • Journal Title: J Public Health Dent Volume: 69(3) Pages: 204-6
• [Journal Article] Poor chewing ability is associated with lower mucosal moisture in elderly individuals (2009)
  • Author(s): Shinkawa T, Hayashida N, Mori K, Washio K, Hashiguchi K, Taira Y, Morishita M, Takamura N
  • Journal Title: Tohoku J Exp Med Volume: 219(4) Pages: 263-267
• [Journal Article] A validated HPLC-fluorescence method with a semi-micro column for routine determination of homocysteine, cysteine and cysteamine, and the relation between the thiol derivatives in normal human plasma (2009)
  • Author(s): Ichinose S, Nakamura M, Maeda M, Ikeda R, Wada M, Nakazato M, Ohba Y, Takamura N, Maeda T, Aoyagi K, Nakashima K
  • Journal Title: Biomed Chromatogr Volume: 23(9) Pages: 935-9
• [Journal Article] Depressive status on Chinese factory workers in Nagasaki, Japan (2009)
  • Author(s): Date Y, Abe Y, Honda S, Ye Z, Takamura N, Tomita M, Osaki M, Aoyagi K
  • Journal Title: Ind Health Volume: 47(4) Pages: 376-82
• [Journal Article] Thyroid function is associated with carotid intima media thickness in euthyroid subjects (2009)
  • Author(s): Takamura N, Akilzhanova A, Hayashida N, Kadota K, Yamasaki H, Usa T, Nakazato M, Maeda T, Ozono Y, Aoyagi K
  • Journal Title: Atherosclerosis Volume: 204(2) Pages: e77-e81
• [Journal Article] Urinary iodine concentrations in urban and rural areas around Chernobyl Nuclear Power Plant (2009)
  • Author(s): Taira Y, Hayashida N, Zhavaranak S, Kozlovsky A, Lyzikov A, Yamashita S, Takamura N
  • Journal Title: Endocr J Volume: 56(2) Pages: 257-61
• [Journal Article] Incidence of chronic obstructive pulmonary disease in general clinics and relevant factors with FEV1/ FVC (2009)
  • Author(s): Fukahori S, Matsuse H, Takamura N, Hirose H, Tsuchida T, Kawano T, Fukushima C, Mizuta Y, Kohno S
  • Journal Title: Int J Clin Prac Volume: 63(2) Pages: 269-74
• [Journal Article] Estimation of blood loss in total knee arthroplasty with and without tourniquet (2009)
  • Author(s): Nishiguchi M, Takamura N, Kono M, Aoyagi K
  • Journal Title: Acta Med Nagasaki Volume: 53(4) Pages: 105-109
• [Book] Oxford Textbook of Endocrinology and Diabetes (2011)
  • Author(s): Nagataki S, Imaizumi M, Takamura N
  • Total Pages: 403-7
  • Publisher: Disorders of iodine excess
• [Remarks]
  • URL: http://www-sdc.med.nagasaki-u.ac.jp/radepi/index.html