Effect of longevity-associated Mitochondrial DNA polymorphism and lifestyle modification on the lifetime of patients with ischemic heart diseases.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590711
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Showa University
• Principal Investigator: KOBA Shinji 昭和大学, 医学部, 講師 (20276546)
• Co-Investigator(Kenkyū-buntansha): YOKOTA Yuuya 昭和大学, 医学部, 講師 (00465105)
• Co-Investigator(Renkei-kenkyūsha): KOKAZE Akatsuki 昭和大学, 医学部, 教授 (70271583)
• Project Period (FY): 2009 – 2011
• Keywords: 冠動脈疾患 / ミトコンドリア遺伝子多型 / 生活習慣 / 心臓リハビリテーション

Research Abstract

This study was approved by the Ethics Committee of the Showa University (Application No. 126). Written informed consent was obtained from 798 patients (656 men and 142 women) before participation. Blood samples were collected from a peripheral vein and then genomic DNA was prepared. The Mt5178 C/A polymorphism was detected by polymerase chain reaction (PCR) and digestion with AluI restriction enzyme. The sequence of primers was: forward 5′-CTTAGCATACTCCTCAATTACCC-3′, reverse 5′-GTGAATTCTTCGATAATGGCCCA-3′. Clinical background data such ashistuory of treatment, the number of hospitalization, clinical outcome, participation of cardiac rehabilitation, family history of coronary heart diseases, diabetes, dyslipidemia, hypertension, smoking status, control of risk factors, is collecting. We divided the study subjects into 3 groups as follows; (1) Juvenile group (onset age <55 years in men and <65 years in women, n=105), (2) high age group (the present age>=80 years, n=189), and (3) the others were classified as the common group (n=504). The allelic of 5178C was observed in 436 patients (355 men and 81 women) and the allelic of 5178A in 362 patients (301 men and 61 women). The allelic frequency of 5178A was somewhat higher in the Juvenile group. In contrast to previous studies, the distribution of the allelic frequency of 5178A/C is similar to the general Japanese population, and there were no significant differences by gender and age. The association between the 5178C/A polymorphism and clinical data isinvestigating.

Research Products

• [Presentation] 急性冠症候群に対する心臓リハビリテーションの長期生命予後改善効果 (2013)
  • Author(s): 木庭新治、横田裕哉、角田史敬、正司 真、長山雅俊、小林洋一
  • Organizer: 第110回日本内科学会総会・講演会
  • Place of Presentation: 東京 (日内会誌 102(臨時増刊号):252, 2013)
  • Year and Date: 2013-04-14
• [Presentation] Highly Reduction of Small Dense LDL-Cholesterol and Increased LDL Size Can Prevent Long-term Cardiovascular Events in Patients with Myocardial Infarction (2013)
  • Author(s): Yokota, Y., Koba, S., Tsunoda, F., Hirano, T., Shoji, M., Satoh, T., Kobayashi, Y.
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜、(Circ. J. 77(Suppl. I):I-2677, 2013.)
  • Year and Date: 2013-03-17
• [Presentation] High Levels of Small Dense LDL-Cholesterol are Strongly Associated with Coronary Events in Patients with Stable Coronary Artery Disease (2013)
  • Author(s): Nishikura, T., Koba, S., Yokota, Y., Hirano, T., Itoh, Y., Tsunoda, F., Shoji, M., Hamazaki, Y., Kobayashi, T.
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜 、(Circ. J. 2013; 77(Suppl. I):I-2840, 2013.)
  • Year and Date: 2013-03-17
• [Presentation] Not Statin but Exercise Based Cardiac Rehabilitation can Increase Cholesterol-rich Large HDL Particles in Patients with Acute Coronary Syndrome (2013)
  • Author(s): Yokota, Y., Koba, S., Tsunoda, F., Hirano, T., Shoji, M., Satoh, T., Tsujita, H., Tsukamoto, S., Hamazaki, Y., Kobayashi, Y.
  • Organizer: 第77回日本循環器学会学術集会Featured Research Session
  • Place of Presentation: 横浜、(Circ. J. 77(Suppl. I):I-642, 2013.)
  • Year and Date: 2013-03-16
• [Presentation] Low HDL-cholesterol and High CRP on Treatment Can Predict Long-term Adverse Outcome in Patients with Myocardial Infarction (2013)
  • Author(s): Yokota, Y., Koba, S., Tsunoda, F., Hirano, T., Shoji, M., Satoh, T., Kobayashi, Y.
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜、(Circ. J. 77(Suppl. I):I-1595, 2013.)
  • Year and Date: 2013-03-16
• [Presentation] LDL-cholesterol/HDL-cholesterol and small dense LDL-cholesterol/HDL-cholesterol ratios are strong predictors for cardiovascular events in patients with stable coronary heart disease (2012)
  • Author(s): Koba, S., Yokota, Y., Hirano, T., Ito, Y., Tsunoda, F., Shoji, M., Kobayashi, Y.
  • Organizer: 第44回日本動脈硬化学会
  • Place of Presentation: 福岡. (学術集会プログラム集, 260, 2012.)
  • Year and Date: 2012-07-20
• [Presentation] Exercise Based Cardiac Rehabilitation Can Increase Cholesterol-rich Large HDL Particles in Patients with Acute Coronary Syndrome (2012)
  • Author(s): Yokota, Y., Koba, S., Hirano, T., Sakurai, M., Tsunoda, F., Satoh, R., Shoji, M., Hamazaki, Y., Kobayashi, Y.
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡. (Circ. J., 76(Suppl. I):I-2520, 2012.)
  • Year and Date: 2012-03-17
• [Presentation] Not Small Dense LDL-cholesterol but Low Levels of HDL-cholesterol Predict Cardiovascular Events in Patients with Stable Coronary Heart Diseases (2012)
  • Author(s): Nishikura, T., Koba, S., Yokota, Y., Hirano, T., Tsunoda, T., Itoh, Y., Satoh, R., Shoji,M., Kobayashi, Y.
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡. (Circ. J., 76(Suppl. I):I-733, 2012.)
  • Year and Date: 2012-03-16
• [Presentation] Not Small Dense LDL but Low Levels of HDL-cholesterol at Onset of Acute Coronary Syndrome as Predictor for Long-term Survival (2011)
  • Author(s): Koba, S., Yokota, Y., Nishikura, T., Hirano, T., Satoh, R., Tsunoda, F., Shoji, M., Katagiri, T., Kobayashi, Y.
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: 横浜. (Circ. J., 75(Suppl. I):I-2143, 2011.)
  • Year and Date: 20110803-04
• [Presentation] Not Small Dense LDL but Low HDL are Strongly Associated with Cardiovascular Events in Patients with Stable Coronary Heart Disease (2011)
  • Author(s): Nishikura, T., Koba, S., Yokota, Y., Hirano, T., Tsunoda, F., Shoji, M., Katagiri, T., Kobayashi, Y.
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: 横浜. (Circ. J., 75(Suppl.I):I-1139, 2011.)
  • Year and Date: 2011-08-03
• [Presentation] 急性冠症候群患者における心臓リハビリテーションはHDL2 コレステロール及びHDL2 アポリポ蛋白A1 を増加させる (2011)
  • Author(s): 横田裕哉、木庭新治、平 野 勉、角田史敬、佐藤龍次、正司 真、長山雅俊、片桐 敬、小林洋一
  • Organizer: 第17回日本心臓リハビリテーション学会
  • Place of Presentation: 大阪、(心臓リハビリテーション, 16(2):S165, 2011.)
  • Year and Date: 2011-07-16
• [Presentation] 心臓リハビリの施行は心筋梗塞発症後10 年間の心血管死だけでなく、非心臓血管死も抑制した (2010)
  • Author(s): 小林睦子、横田裕哉、木庭新治、角田史敬、佐藤龍次、正司 真、伴 良久、鈴木 洋、長山雅俊、片桐 敬、小林洋一
  • Organizer: 第16回日本心臓リハビリテーション学会
  • Place of Presentation: 鹿児島. (心臓リハビリテーション, 15(Suppl.):S183, 2010.)
  • Year and Date: 2010-07-18
• [Presentation] 心臓リハビリテーションにおける食習慣の改善と心筋梗塞後の生命予後改善効果との関連 (2010)
  • Author(s): 木庭新治、横田裕哉、中田美江、江川麻里子、玉木大輔、角田史敬、近藤武志、伴 良久、正司 真 、鈴 木 洋、長山雅俊、片桐 敬、小林洋一
  • Organizer: 第16回日本心臓リハビリテーション学会
  • Place of Presentation: 鹿児島. (心臓リハビリテーション, 15(Suppl.):S162, 2010.)
  • Year and Date: 2010-07-17
• [Presentation] Marked increases of large HDL cholesterol in cardiac rehabilitation (2010)
  • Author(s): Yokota, Y., Koba, S., Munetsugu, Y., Hirano, T., Omori, Y., Satoh, R., Satoh, T., Shoji, M., Geshi, E., Katagiri, T., Kobayashi, Y.
  • Organizer: 第74回日本循環器学会総会
  • Place of Presentation: 京都. (Circ. J., 74 (Supplement-1):384, 2010.)
  • Year and Date: 2010-03-07