2011 Fiscal Year Final Research Report
A cohort study on the effect of vitamin D on fracture and bone mineral density as outcomes of osteoporosis
| Project/Area Number |
21590722
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Niigata University of Health and Welfare |
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Principal Investigator |
SAITO Toshiko 新潟医療福祉大学, 健康科学部, 教授 (40339958)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Kazutoshi 新潟大学, 医歯学系, 教授 (70207869)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 保健栄養 / 疫学 / 骨粗鬆症 / 骨折 |
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| Research Abstract |
The aim of this study was to determine preventive effects of vitamin D on bone parameters in relation to osteoporosis. A five-year and six-year cohort studies were conducted in Yokogoshi and Muramatsu, respectively. Subjects were 595 women aged between 55 and 74 years in Yokogoshi and 775 women aged 70 years and over in Muramatsu. Serum 25-hydroxyvitamin D(25[OH] D) at baseline was measured as an index of vitamin D status, and outcomes were bone mineral density(BMD) and incident osteoporotic fractures, respectively. Although 25(OH) D was not associated a five-year change in BMD of hip or lumbar spine, the high 25(OH) D(≧71 nmol/L) associated with lower risk of fracture.
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