2011 Fiscal Year Final Research Report
Development of methods for identification and quantitation of fentanyl related designer drugs and their metabolites
| Project/Area Number |
21590744
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Showa University |
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Principal Investigator |
SATO Keizo 昭和大学, 医学部, 教授 (20162422)
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| Co-Investigator(Kenkyū-buntansha) |
LEE Xiao-peng 昭和大学, 医学部, 講師 (90245829)
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Shinichi 昭和大学, 医学部, 客員教授 (00356198)
FUJISHIRO Masaya 昭和大学, 医学部, ポストドクター (00527161)
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| Project Period (FY) |
2009 – 2011
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| Keywords | フェンタニル・デザイナードラッグ・GC / GC/MS・HPLC / HPLC/MS・ミクロ固相抽出・フェノチアジン |
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| Research Abstract |
In order to prove narcotic abuse, detection and identification of its metabolites, which reflect peculiar chemical structure of the narcotic, in urine obtained from an abuser of the drug is essential. Though α-methylfentanyl is the representative designer drug of the fentanyl and its related compounds, major metabolites of the narcotic do not reflect peculiar chemical structure of the drug. In this study, we were able to detect and identify four minor metabolites, which reflect peculiar chemical structure of the α-methylfentanyl in urine obtained from rats to which we gave the narcotic orally. In addition, we could develop not only the method for solid-phase microextraction of the α-methylfentanyl from urine or blood but also that for quantitation of the drug in urine or blood with gas chromatography(GC)/mass spectrometry(MS).
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