PET分子イメージングによる代替医療の治療効果発現メカニズムの科学的検証

2010 Fiscal Year Annual Research Report

• Project/Area Number: 21590754
• Research Institution: Tohoku University
• Principal Investigator: 田代 学 東北大学, サイクロトロン・ラジオアイソトープセンター, 准教授 (00333477)
• Keywords: 代替療法 / ポジトロン断層法(PET) / 局所脳糖代謝 / フルオロデオキシグルコース(FDG) / ストレス / カイロプラクティック / 鍼灸治療

Research Abstract

代替医療の治療手技の一つであるカイロプラクティックによる治療効果を科学的に分析するための臨床研究を実施した。頸部痛、肩こりがあるがそれ以外の目立った症状および他の疾患がない男性12名を対象として、ポジトロン断層法(PET)による測定を行った。測定に用いたトレーサーは、フルオロデオキシグルコース(FDG)であり、カイロプラクティック施術後と無治療待機時の安静状態の局所脳糖代謝を比較した。PET測定の前後に、主観的な痛みの自覚、ストレスの自覚について質問票を用いて調査した。また客観的指標として、心拍ゆらぎ解析による自律神経機能の変化、唾液アミラーゼ濃度測定によるストレス評価、頚部～肩にかけての筋硬度の評価を合わせて行った。本研究は東北大学大学院医学系研究科倫理委員会の承認を得て実施した。
PET画像解析の結果、施術後の安静状態における脳糖代謝の亢進部位と低下部位が観察された。脳糖代謝亢進部位としては、前頭前野や帯状回などが観察され、脳糖代謝低下部位としては小脳虫部が観察された。同時に実施した主観的評価では、痛みの自覚が施術後に有意に軽減し、主観的ストレスの自覚も軽減していることが示された。客観的指標として実施した心拍ゆらぎ解析では有意な自律神経活動の差異が検出できなかったが、唾液腺アミラーゼでは施術後に有意にストレスが軽減していることが示唆された。
全体としては、施術後には対象者がリラクゼーション状態にあり、それに対応して発生した脳内変化がPETで測定できたものと考えられた。今後は、さらに対象者数を増やして結果の安定性を評価することを予定している。

Research Products

• [Journal Article] Effects of presence of a familiar pet dog on regional cerebral activity in healthy volunteers : a positron emission tomography study (2011)
  • Author(s): Sugawara A, Masud MM, Yokoyama A, Mizutani W, Watanuki S, Yanai K, Itoh M, Tashiro M
  • Journal Title: Anthrozoos Volume: (未定)(印刷中)
  • Peer Reviewed
• [Journal Article] Regional cerebral metabolic changes in patients with neck pain following chiropractic spinal manipulation : [18F]FDG PET Analysis (2010)
  • Author(s): Ogura T, Tashiro M, Masud M, Watanuki S, Shibuya K, Yamaguchi K, Itoh M, Fukuda H, Yanai K
  • Journal Title: Altem Ther Health Med Volume: (未定)(印刷中)
  • Peer Reviewed
• [Journal Article] In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET (2010)
  • Author(s): Okamura N, Shiga Y, Furumoto S, Tashiro M, Tsuboi Y, Furukawa K, Yanai K, Iwata R, Arai H, Kudo Y, Itoyama Y, Doh-Ura K
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 37 Pages: 934-941
  • Peer Reviewed
• [Journal Article] Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227 : comparis on to FDG-PET (2010)
  • Author(s): Furukawa K, Okamura N, Tashiro M, Waragai M, Furumoto S, Iwata R, Yanai K, Kudo Y, Arai H
  • Journal Title: J Neurol Volume: 257 Pages: 721-727
  • Peer Reviewed
• [Journal Article] Function of the shoulder muscles during arm elevation : an assessment using positron emission tomography (2010)
  • Author(s): Omi R, Sano H, Ohnuma M, Kishimoto KN, Watanuki S, Tashiro M, Itoi E
  • Journal Title: J Anat Volume: 216 Pages: 643-649
  • Peer Reviewed
• [Journal Article] Application of Positron Emission Tomography (PET) in Physical Medicine (2010)
  • Author(s): Masud MM, Fujimoto T, Watanuki S, Miyake M, Itoh M, Tashiro M
  • Journal Title: Mymensingh Med J Volume: 19 Pages: 110-115
  • Peer Reviewed
• [Journal Article] Next-day residual sedative effect after nighttime administration of an over-the-counter antihistamine sleep aid, diphenhydramine, measured by positron emission tomography (2010)
  • Author(s): Zhang D, Tashiro M, Shibuya K, Okamura N, Funaki Y, Yoshikawa T, Kato M, Yanai K
  • Journal Title: J Clin Psychopharmacol Volume: 30 Pages: 694-701
  • Peer Reviewed
• [Journal Article] Long-tem performance evaluation of positron emission tomography : analysis and proposal of a maintenance protocol for long-term utilization (2010)
  • Author(s): Watanuki S, Tashiro M, Miyake M, Ishikawa Y, Itoh M, Yanai K, Sakemi Y, Fukuda H, Ishii K
  • Journal Title: Ann Nucl Med Volume: 24 Pages: 461-468
  • Peer Reviewed
• [Journal Article] In vivo visualization of alpha-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy] benzoxazole positron emission tomography in multiple system atrophy (2010)
  • Author(s): Kikuchi A, Takeda A, Okamura N, Tashiro M, Hasegawa T, Furumoto S, Kobayashi M, Sugeno N, Baba T, Miki Y, Mori F, Wakabayashi K, Funaki Y, Iwata R, Takahashi S, Fukuda H, Arai H, Kudo Y, Yanai K, Itoyama Y
  • Journal Title: Brain Volume: 133 Pages: 1772-1778
  • Peer Reviewed
• [Journal Article] Voxel-based analysis of amyloid positron emission tomography probe[11C]BF-227 uptake in mild cognitive impairment and Alzheimer's disease (2010)
  • Author(s): Shao H, Okamura N, Sugi K, Furumoto S, Furukawa K, Tashiro M, Iwata R, Matsuda H, Kudo Y, Arai H, Fukuda H, Yanai K
  • Journal Title: Dement Geriatr Cogn Disord Volume: 30 Pages: 101-111
  • Peer Reviewed
• [Journal Article] Brain activity following esophageal acid infusion using positron emission tomography (2010)
  • Author(s): Kobayashi S, Abe Y, Tashiro M, Koike T, Iijima K, Imatani A, Ohara S, Watanabe S, Fukudo S, Shimosegawa T
  • Journal Title: World J.Gastroenterol. Volume: 16 Pages: 5481-5489
  • Peer Reviewed
• [Journal Article] Neural correlates of forgiveness for moral transgressions involving deception (2010)
  • Author(s): Hayashi A, Abe N, Ueno A, Shigemune Y, Mori E, Tashiro M, Fujii T
  • Journal Title: Brain Res Volume: 1332 Pages: 90-99
  • Peer Reviewed
• [Journal Article] Right temporal-lobe contribution to the retrieval of family relationships in person identification (2010)
  • Author(s): Abe N, Fujii T, Ueno A, Shigemune Y, Suzuki M, Tashiro M, Mori E
  • Journal Title: Neurosci Lett Volume: 486 Pages: 10-13
  • Peer Reviewed
• [Journal Article] Effects of emotion and reward motivation on neural correlates of episodic memory encoding : a PET study (2010)
  • Author(s): Shigemune Y, Abe N, Suzuki M, Ueno A, Mori E, Tashiro M, Itoh M, Fujii T
  • Journal Title: Neurosci Res Volume: 67 Pages: 72-79
  • Peer Reviewed
• [Journal Article] The safety of newer antihistamines : Evaluation of their sedative properties by positron emission tomography
  • Author(s): Yanai K, Zhang D, Tashiro M, Shibuya K, Naganuma, Harada R, Nakamura T, Yoshikawa T, Okamura N
  • Journal Title: Expert Opinion on Drug Safety Volume: 2011(未定)(印刷中)
  • Peer Reviewed
• [Journal Article] Brain histamine H1 receptor occupancy of loratadine measured by PET : Comparison of H1 receptor occupancy and proportional impairment ratio
  • Author(s): Kubo N, Senda M, Osumi Y, Sakamoto S, Matsumoto K, Tashiro M, Okamura N, Yanai K
  • Journal Title: Human Psychopharmacol Volume: 2011(未定)(印刷中)
  • Peer Reviewed
• [Presentation] Pharmacokinetics of [18F]FACT, a new 18F-labeled amyloid imaging agent, in the brain Alzheimer's disease patients. Annual Meeting of EANM (2010)
  • Author(s): Tashiro M, Okamura N, Watanuki S, Furumoto S, Furukawa K, Funaki Y, Iwata R, Kudo Y, Arai H, Yanai K
  • Organizer: Annual Meeting of EANM
  • Place of Presentation: Vienna, Austria
  • Year and Date: 20101011-20101114
• [Presentation] Quantitative Analysis of amyloid beta deposition in the brain of Alzheimer's disease patients using PET and [11C]BF-227 (2010)
  • Author(s): Tashiro M, Okamura N, Watanuki S, Furumoto S, Furukawa K, Funaki Y, Iwata R, Kudo Y, Arai H, Yanai K
  • Organizer: Annual Meeting of EANM
  • Place of Presentation: Vienna, Austria
  • Year and Date: 20101011-20101114
• [Presentation] Pharmacokinetics of a new 18F-labeled amyloid imaging agent, [18F]FACT, in Alzheimer's disease patients (2010)
  • Author(s): Tashiro M, Okamura N, Watanuki S, Furumoto S, Furukawa K, Funaki Y, Iwata R, Kudo Y, Arai H, Yanai K
  • Organizer: World Molecular Imaging Conference 2010
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20100908-20100911
• [Presentation] Quantitative Analysis of amyloid b deposition in the brain of Alzheimer's disease patients using PET with [11C]BF-227 and [18F]FACT (2010)
  • Author(s): Tashiro M, Okamura N, Furumoto S, Watanuki S, Kumagai K, Furukawa K, Funaki Y, Kimura Y, Iwata R, Kudo Y, Arai H, Watabe H, Yanai K
  • Organizer: World Congress on Biomechanics
  • Place of Presentation: Singapore, Singapore
  • Year and Date: 20100802-20100804
• [Presentation] Recent interdisciplinary functional/molecular imaging studies at Tohoku University, Sendai, Japan (2010)
  • Author(s): Tashiro M
  • Organizer: Symposium 150 Jahre MVZ : Interdisciplinarity "Past-Present-future"
  • Place of Presentation: Oldenburg, Germany
  • Year and Date: 2010-09-18
• [Book] Quantitative Analysis of Amyloid β Deposition in Patients with Alzheimer's Disease Using Positr on Emission Tomography. IN : Early Detection and Rehabilitation Technologies for Dementia : Neuroscience and Biomedical Applications (2011)
  • Author(s): Tashiro M, Okamura N, Watanuki S, Furumoto S, Furukawa K, Funaki Y, Iwata R, Kudo Y, Arai H, Watabe H, Yanai K
  • Total Pages: 218-228
  • Publisher: IGI Global. Philadelphia, USA
• [Book] PET Studies of Brain Metabolism in Exercise Research. IN : Functional Neuroimaging in Exercise and Sport Sciences (2011)
  • Author(s): Tashiro M, Fujimoto T, Masud MM, Khondkar S, Watanuki S, Yanai K, Itoh M, Ishii K
  • Publisher: Springer. New York, USA(印刷中)
• [Book] こころを画像で診る:その方法と患者心理研究への応用性.腎と透析.特集号「維持透析患者の補完代替医療ガイドブック」 (2011)
  • Author(s): 田代学、伊藤正敏
  • Publisher: 東京医学社(印刷中)
• [Book] Molecular and functional imaging for drug development and elucidation of disease mechanisms. Molecular Imaging for Integrated Medical Therapy (2010)
  • Author(s): Tashiro M, Fujitmoto T, Okamura N, Iwata R, Yanai K
  • Total Pages: 222-234
  • Publisher: Springer. New York, USA
• [Book] ヒスタミンH1受容体占拠率による脳内移行性評価.In:創薬技術の革新マイクロドーズからPET分子イメージングへの新展開 (2010)
  • Author(s): 谷内一彦、田代学、古本祥三、吉川雄朗、岡村信行
  • Total Pages: 147-152
  • Publisher: メディカルドゥ社