Scientific evaluation of therapeutic effects and mechanism of alternative therapies using PET molecular imaging technique.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21590754
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: TASHIRO Manabu 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00333477)
• Co-Investigator(Renkei-kenkyūsha): SEKI Takashi 東北大学, 医学系研究科, 講師 (90372292) ; FUJIMOTO Toshihiko 東北大学, 高等教育開発推進センター, 准教授 (00229048) ; YANAI Kazuhiko 東北大学, 医学系研究科, 教授 (50192787)
• Project Period (FY): 2009 – 2011
• Keywords: カイロプラクティック / ストレス / ヒスタミン / フルオロデオキシグルコース(FDG) / ポジトロン断層法(PET) / 代替医療 / 局所脳活動 / 鍼灸治療

Research Abstract

Histamine release in the brain of healthy volunteers evaluated by PET and[11C] doxepin investigation did not show significant changes induced by psychological stress(calculation task). Brain glucose metabolism in the brain of men with neck and shoulder pain showed significant changes associated with relaxation induced by chiropractic treatment and by the presence of accompanying animals. Glucose metabolic change measurement with PET and[18] FDG seems to be useful for evaluation of alternative therapies.

Research Products

• [Journal Article] [11C] Doxepin binding to histamine H1 receptors in living human brain in association with attentive waking and circadian rhythm (2012)
  • Author(s): Shibuya K, Funaki Y, Hiraoka K, Yoshikawa T, Miyake M, Watanuki S, Shao H, Tashiro M, Yanai K
  • Journal Title: Frontiers in Systems Neuroscience Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Effects of presence of a familiar pet dog on regional cerebral activity in healthy volunteers : a positron emission tomography study (2012)
  • Author(s): Sugawara A, Masud MM, Yokoyama A, Mizutani W, Watanuki S, Yanai K, Itoh M, Tashiro M
  • Journal Title: Anthrozoos Volume: Vol.25 Pages: 25-34
  • Peer Reviewed
• [Journal Article] Regional cerebral metabolic changes in patients with neck pain following chiropractic spinal manipulation : [18F] FDG PET Analysis (2011)
  • Author(s): Ogura T, Tashiro M, Masud M, Watanuki S, Shibuya K, Yamaguchi K, Itoh M, Fukuda H, Yanai K
  • Journal Title: Altern Ther Health Med Volume: Vol.17 Pages: 12-14
  • Peer Reviewed
• [Journal Article] 心身の活動と健康生成に関するイメージング研究 (2011)
  • Author(s): 田代学
  • Journal Title: Isotope News Volume: Vol.685 Pages: 2-7
• [Journal Article] Application of Positron Emission Tomography(PET)in Physical Medicine (2010)
  • Author(s): Masud MM, Fujimoto T, Watanuki S, Miyake M, Itoh M, Tashiro M
  • Journal Title: Mymensingh Med J Volume: Vol.19 Pages: 110-115
  • Peer Reviewed
• [Journal Article] Brain activity following esophageal acid infusion using positron emission tomography (2010)
  • Author(s): Kobayashi S, Abe Y, Tashiro M, Koike T, Iijima K, Imatani A, Ohara S, Watanabe S, Fukudo S, Shimosegawa T
  • Journal Title: World J Gastroenterol Volume: Vol.16 Pages: 5481-5489
  • Peer Reviewed
• [Journal Article] Redistribution of whole-body Energy Metabolism by Exercise : A Positron Emission Tomography study (2009)
  • Author(s): Masud MM, Fujimoto T, Tashiro M, Miyake M, Watanuki S, Itoh M
  • Journal Title: Ann Nucl Med Volume: Vol.23 Pages: 81-88
  • Peer Reviewed
• [Journal Article] Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention (2009)
  • Author(s): Fukudo S, Kanazawa M, Mizuno T, Hamaguchi T, Kano M, Watanabe S, Sagami Y, Shoji T, Endo Y, Hongo M, Itoyama Y, Yanai K, Tashiro M, Aoki M
  • Journal Title: Neuroimage Volume: Vol.47 Pages: 946-951
  • Peer Reviewed
• [Journal Article] Evaluation of individual skeletal muscle activity by glucose uptake during pedaling exercise at different workloads using positron emission tomography (2009)
  • Author(s): Gondoh Y, Tashiro M, Itoh M, Masud MM, Sensui H, Watanuki S, Ishii K, Takekura H, Nagatomi R, Fujimoto T
  • Journal Title: J Appl Physiol Volume: Vol.107 Pages: 599-604
  • Peer Reviewed
• [Journal Article] Dose dependency of brain histamine H(1)receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with[11C] doxepin (2009)
  • Author(s): Tashiro M, Kato M, Miyake M, Watanuki S, Funaki Y, Ishikawa Y, Iwata R, Yanai K
  • Journal Title: Hum Psychopharmacol Volume: Vol.24 Pages: 540-548
  • Peer Reviewed
• [Presentation] Neuroimaging evaluation of regional brain responses to alternative therapies : [18F] FDG PET studies (2012)
  • Author(s): Tashiro M, Ogura T, Sugawara A, Duan X, Masud M, Watanuki S, Itoh M, Yanai K
  • Organizer: European Conference of Radiology(ECR)
  • Place of Presentation: Vienna, Austria
  • Year and Date: 20120301-05
• [Presentation] 用手療法の有用性に関するFDG-PET研究 (2011)
  • Author(s): 小倉毅, 田代学, メヘディ・マスード, 四月朔日聖一, 平岡宏太良, 渋谷勝彦, 谷内一彦, 山口慶一郎, 伊藤正敏
  • Organizer: 日本核医学会学術総会
  • Place of Presentation: 茨城県つくば市
  • Year and Date: 20111027-29
• [Presentation] Measurement of histamine release change in living human brain associated with stress and circadian rhythm (2010)
  • Author(s): Shibuya K, Tashiro M, Watanuki S, Masud M, Miyake M, Kumagai K, Ishikawa Y, Iwata R, Yanai K
  • Organizer: 6th World Congress of Biomechanics and 14th International Conference on Biomedical Engineering
  • Place of Presentation: Singapore
  • Year and Date: 20100803-04
• [Presentation] Scientific Evaluation on Effects of Chiropractic Treatment, a Type of Manual Therapy, using Magnetic Resonance Imaging(MRI)and Positron Emission Tomography(PET) (2010)
  • Author(s): Ogura T, Tashiro M, Masud M, Watanuki S, Shibuya K, Itoh M, Fukuda H, Yanai K
  • Organizer: 6th World Congress of Biomechanics and 14th International Conference on Biomedical Engineering
  • Place of Presentation: Singapore
  • Year and Date: 20100803-04
• [Presentation] Human functional and molecular imaging using positron emission tomography(PET)for health promotion sciences (2009)
  • Author(s): Tashiro M, Masud MM, Jeong M, Fujimoto T, Miyake M, Watanuki S, Itoh M, Yanai K
  • Organizer: 3rd International Symposium of Nanomedicine(ISNM2009)
  • Place of Presentation: Okazaki, Aichi
  • Year and Date: 20091104-05
• [Presentation] 鍼灸治療による脳血流反応の観察 (2009)
  • Author(s): 田代学、関隆志、紺野亮、小林祐太、丸山将宏, 四月朔日聖一, 古川勝敏
  • Organizer: 日本統合医療学会
  • Place of Presentation: 東京
  • Year and Date: 2009-11-22
• [Presentation] 鍼灸治療による脳血流反応の観察 (2009)
  • Author(s): 田代学、関隆志、紺野亮、小林祐太
  • Organizer: 日本核医学会総会
  • Place of Presentation: 北海道旭川市
  • Year and Date: 2009-10-02
• [Presentation] Evaluation of cerebral activity and autonomic function in humans in vivo during accompanying with animal : a PET study (2009)
  • Author(s): Masud M, Sugawara A, Yokoyama A, Mizutani W, Watanuki S, Tashiro M, Itoh M
  • Organizer: 日本核医学会総会
  • Place of Presentation: 北海道旭川市
  • Year and Date: 2009-10-02
• [Book] 頸部痛患者におけるカイロプラクティック施術後の局所脳代謝変化 (2011)
  • Author(s): 小倉毅、田代学、メヘディ・マスード、四月朔日聖一、渋谷勝彦、谷内一彦、山口慶一郎、伊藤正敏
  • Total Pages: 44-51
  • Publisher: 日本カイロプラクティック徒手医学会
• [Book] Nano-bio-imaging with radiopharmaceuticals and its application to health sciences (2011)
  • Author(s): Tashiro M, Hiraoka K, Watanuki S, Masud MM, Miyake M, Kumagai K, Ogura T, Yanai K
  • Total Pages: 35-38
  • Publisher: Research Publishing Services
• [Book] Molecular and functional imaging for drug development and elucidation of disease mechanisms using positron emission tomography (PET) (2010)
  • Author(s): Tashiro M, Fujimoto T, Okamura N, Iwata R, Yanai K
  • Total Pages: 222-234
  • Publisher: Springer Japan
• [Book] PET Studies of Brain Metabolism in Exercise Research
  • Author(s): Tashiro M, Fujimoto T, Masud MM, Khondkar S, Watanuki S, Yanai K, Itoh M, Ishii K
  • Publisher: Springer
• [Remarks]
  • URL: http://kakuigaku.cyric.tohoku.ac.jp/index.html