2011 Fiscal Year Final Research Report
Analysis of Target Molecules and Pathogenesis with Traditional Japanese Medicine on the Mechanism of Hypoxic Adaptative Response
| Project/Area Number |
21590758
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of Toyama |
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Principal Investigator |
GOTO Hirozo 富山大学, 大学院・医学薬学研究部, 准教授 (40313598)
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| Co-Investigator(Kenkyū-buntansha) |
HIKIAMI Hiroaki 富山大学, 大学病院, 講師 (70345586)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 東洋医学 |
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| Research Abstract |
Recently the hypoxic state of the biological body and the activation of hypoxia inducible factor(HIF) has attracted attention. HIF has been also reported to influence the end-stage of renal failure. In this study, we studied the effect of hachimijiogan on HIF levels in renal failure rats. The results were that the administration of hachimijiogan decreased the uric protein and increased the amount of HIF protein in the renal cortex. Furthermore we studied the active components of hachimijiogan using renal tubular epithelial cultured cells. Cinnamaldehyde and paonol were found to increase the amount of HIF.
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Research Products
(5 results)
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[Journal Article] Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1alpha in the Remnant Kidney Model2011
Author(s)
Oka H., Goto H., Koizumi K., Nakamura S., Tsuneyama K., Zhou Y., Jo M., Fujimoto T., Sakurai H., Shibahara N., Saiki I., and Shimada Y.
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Journal Title
Evid Based Complement Alternat Med
Volume: 348686
Peer Reviewed
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[Journal Article] Cinnamaldehyde and paeonol increase HIF-1αactivity in proximal tubular epithelial cells under hypoxia2011
Author(s)
Oka H., Goto H., Koizumi K., Nogami T., Watari H., Nakamura S., Zhou Y., Sakurai H., Shibahara N., Saiki I., Shimada Y.
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Journal Title
Journal of Traditional Medicine
Volume: 28
Pages: 149-157
Peer Reviewed
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